PLXNB3 and MAGI3

Number of citations of the paper that reports this interaction (PubMedID 12421765)
41

Data Source:
HPRD (two hybrid)

		PLXNB3	MAGI3
Description		plexin B3	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction
	Molecular Function	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process
Pathways		Other semaphorin interactions
Drugs
Diseases
GWAS			Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		8 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 MAGI2 MAGI3 RIT2 SPOCK2	18 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FMR1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2
Entrez ID		5365	260425
HPRD ID		02198	11290
Ensembl ID		ENSG00000198753	ENSG00000081026
Uniprot IDs		A8K920 Q9ULL4	Q5TCQ9
PDB IDs			3SOE
Enriched GO Terms of Interacting Partners?
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