PLXNB1 and PLXNA1

Number of citations of the paper that reports this interaction (PubMedID 25315821)
14

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		PLXNB1	PLXNA1
Description		plexin B1	plexin A1
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Semaphorin Receptor Complex Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding Signaling Receptor Activity	Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Inhibitory Synapse Assembly	Negative Regulation Of Cell Adhesion Multicellular Organism Development Regulation Of Cell Shape Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Neuron Projection Extension
Pathways		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse RHOD GTPase cycle	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions RHOD GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576 29875488) Platelet count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 31469255) Weight ( 28552196) Whole-brain volume ( 21116278)
Interacting Genes		14 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4	10 interacting genes: AKT1 FES FGFR2 L1CAM NRP1 NRP2 PLXNB1 RHOD RND1 SEMA6D
Entrez ID		5364	5361
HPRD ID		03032	11868
Ensembl ID		ENSG00000164050	ENSG00000114554
Uniprot IDs		O43157	Q9UIW2
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W
Enriched GO Terms of Interacting Partners?
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