PLSCR1 and DMRT3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PLSCR1	DMRT3
Description		phospholipid scramblase 1	doublesex and mab-3 related transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Magnesium Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Virus Receptor Activity DNA Binding Nuclease Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding Lead Ion Binding CD4 Receptor Binding Mercury Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Response To Lead Ion Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phosphatidylserine Exposure On Apoptotic Cell Surface Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Chromosome Separation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Regulation Of Transcription By RNA Polymerase II Sex Differentiation Adult Walking Behavior Transmission Of Nerve Impulse Ventral Spinal Cord Interneuron Specification Regulation Of Odontogenesis Of Dentin-containing Tooth Male Sex Differentiation
Pathways
Drugs
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756)	Dupuytren's disease ( 28886342) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		130 interacting genes: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF6 CRK CRKL CRY1 CTBP1-DT CTSZ DAZAP2 DDIAS DEF6 DEPP1 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM107A FBLN1 FBXL18 FGFR2 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 INTS11 IP6K2 IQCN KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RAMAC RASD1 RBL1 RERE RGS3 RXRB SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C VSIR YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF688 ZNF764	86 interacting genes: AKAP8L ASPG ATN1 ATP6V0D1 C11orf1 CCNDBP1 CYSRT1 FHL3 FHL5 FOXN1 FRS3 GPSM1 GRN HSF2BP INCA1 KHDRBS3 KPRP KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LASP1 LMO2 MDFI MEOX2 MGAT5B MID2 MTUS2 MYOZ3 NBPF19 NFKBID NHLRC4 NOTCH2NLA OIP5 PFDN5 PLEKHF2 PLSCR1 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSME3 RBPMS REL RFX6 RUSC1 SAT1 SPAG8 TCF4 TLE5 TRAF1 TRIM23 TRIM27 TRIP6 TSC1 TTC19 UBASH3B USP54 WWOX YPEL3 ZFY ZMYND12 ZNF438
Entrez ID		5359	58524
HPRD ID		08855	16827
Ensembl ID		ENSG00000188313	ENSG00000064218
Uniprot IDs		O15162	Q9NQL9
PDB IDs		1Y2A
Enriched GO Terms of Interacting Partners?
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