PLEC and ITGB4

Number of citations of the paper that reports this interaction (PubMedID 14668477)
45

Data Source:
HPRD (in vivo, two hybrid)

		PLEC	ITGB4
Description		plectin	integrin subunit beta 4
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Z Disc Hemidesmosome Axon Dendrite Sarcolemma Costamere Myelin Sheath Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Basement Membrane Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Basal Plasma Membrane Cell Surface Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Dystroglycan Binding RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Protein Self-association Cadherin Binding	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding
	Biological Process	Cell Morphogenesis Leukocyte Migration Involved In Immune Response Keratinocyte Development Negative Regulation Of Protein Kinase Activity Nucleus Organization Gene Expression Fibroblast Migration T Cell Chemotaxis Skeletal Myofibril Assembly Transmission Of Nerve Impulse Respiratory Electron Transport Chain Actin Cytoskeleton Reorganization Hemidesmosome Assembly Cellular Response To Extracellular Stimulus Response To Food Peripheral Nervous System Myelin Maintenance Adherens Junction Organization Cellular Protein Localization Multicellular Organism Growth Wound Healing Regulation Of Vascular Permeability Protein-containing Complex Subunit Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Sarcomere Organization Myoblast Differentiation Skeletal Muscle Fiber Development Cardiac Muscle Cell Development Establishment Of Skin Barrier Mitochondrion Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Hydrostatic Pressure Cellular Response To Fluid Shear Stress Tight Junction Organization Actomyosin Contractile Ring Assembly Actin Filament Organization Regulation Of ATP Citrate Synthase Activity	Autophagy Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Hemidesmosome Assembly Peripheral Nervous System Myelin Formation Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Filopodium Assembly Mesodermal Cell Differentiation Cell Motility Trophoblast Cell Migration
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly	Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly
Drugs			R1295
Diseases
GWAS		Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 28107422 26561523) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip index ( 34021172) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricular ejection fraction (MTAG) ( 33495596) Left ventricular global radial strain (MTAG) ( 33495596) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Periodontitis (stage III/IV grade C) ( 33745150) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)
Interacting Genes		24 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SNAPIN SPTA1 SPTAN1 SUMO2 UBC VIM	59 interacting genes: ADAMTSL4 ALOX12 APPBP2 ATXN1 CLCA1 CLCA2 COL17A1 CYSRT1 DST ECM1 EIF6 ERBB2 ERBIN FYN GRB2 HOXA1 ITGA6 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP4-2 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 MDFI MET MID2 MTUS2 MYF5 NBPF19 NOTCH2NLA PLEC PLSCR4 POU2AF1 PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 TGM1 TRIP6 VIM YES1 YWHAB YWHAQ
Entrez ID		5339	3691
HPRD ID		03180	00946
Ensembl ID		ENSG00000178209	ENSG00000132470
Uniprot IDs		Q15149	A0A024R8K7 A0A024R8N2 A0A024R8T0 B7ZLD8 P16144
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I	1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL
Enriched GO Terms of Interacting Partners?
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