PLCG2 and TWIST2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
26

Data Source:
BioGRID (two hybrid)

		PLCG2	TWIST2
Description		phospholipase C gamma 2	twist family bHLH transcription factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Intracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Protein Binding Protein Kinase Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Protein Tyrosine Kinase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Cell Activation Response To Yeast Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Follicular B Cell Differentiation Positive Regulation Of Dendritic Cell Cytokine Production Phosphatidylinositol Biosynthetic Process Phospholipid Catabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Regulation Of Lipid Metabolic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Response To Axon Injury Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion Cellular Response To Lipid Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of I-kappaB Phosphorylation Cellular Response To Lectin	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Cell Migration Developmental Process Negative Regulation Of Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Erythropoietin activates Phospholipase C gamma (PLCG) FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Alzheimer's disease ( 34099642) Alzheimer's disease (late onset) ( 28714976) Blood protein levels ( 30072576) Breast cancer (menopausal hormone therapy interaction) ( 24080446) Ceramide levels (C24:0) ( 32489964) Chronic widespread musculoskeletal pain ( 33331911) Coronary artery disease ( 29212778 33020668) Dental caries (decayed, missing and filled teeth) ( 31533690) Height ( 28552196) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 33031748) Takayasu arteritis ( 33308445) Ulcerative colitis ( 28067908) Upper eyelid morphology ( 29921221) Venous thromboembolism ( 31420334 31676865) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blond vs. brown/black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Male-pattern baldness ( 29146897 27182965 28196072) Morning person ( 30696823) Pancreas volume ( 34128465) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		57 interacting genes: AR ASB9 BLK BLNK BTK CBLB CD19 DAPP1 EGFR ELK1 EPOR EPYC ERBB2 ERBB3 ERBB4 ESD FCER1G FLT1 FYN GAB1 GAB2 GABPB2 HCK HSPD1 IRF8 IRS1 ISL1 ITK JAK1 JAK2 KCTD17 KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LHX8 LIME1 LYN MET NPM1 PRKD1 PTPN6 PTTG1 RALBP1 RTL10 SETD9 SH3BP2 SHC1 SYK TEC TP53 TWIST2 ZKSCAN7 ZNF512B	9 interacting genes: CRK FERD3L GLIS2 MEF2C PLCG2 SREBF1 TCF12 TCF3 TCF4
Entrez ID		5336	117581
HPRD ID		02570	09616
Ensembl ID		ENSG00000197943	ENSG00000233608
Uniprot IDs		P16885	A1MB48 Q8WVJ9
PDB IDs		2K2J 2W2W 2W2X
Enriched GO Terms of Interacting Partners?
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