TM6SF2 and BCL2L13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TM6SF2	BCL2L13
Description		transmembrane 6 superfamily member 2	BCL2 like 13
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Nucleus Mitochondrion Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Lipid Homeostasis	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874 33339817) Aspartate aminotransferase levels ( 33547301 34315874) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 26482880) Cirrhosis (multi-trait analysis) ( 33310085) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Liver enzyme levels (alanine transaminase) ( 33972514) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Nonalcoholic fatty liver disease ( 24531328 29385134) Nonalcoholic steatohepatitis ( 32298765) Percent liver fat ( 34128465) Schizophrenia ( 25056061 29483656 23974872) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549 32154731 29403010 33339817) Type 2 diabetes ( 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitamin levels ( 23696881) Waist-to-hip ratio adjusted for BMI ( 34021172)	Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Eosinophil counts ( 32888494) Granulocyte count ( 27863252) Hemoglobin levels ( 32327693) Interleukin-10 levels ( 22205395) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ARL13B BCL2L13 FAM209A HIBADH KCNJ6 MUC1 PVR SCN3B SSMEM1 TMEM237	56 interacting genes: ADIPOQ AGTRAP AIG1 APOD APP AQP1 BET1 C4orf3 CD53 CLDN19 CRB3 DEFB127 ERG28 ERMP1 FAM210B FXYD3 FZD7 GABARAPL2 GALNT2 GAST HMOX2 IL17RA JAGN1 LAT LPAR3 MAL MTNR1B NINJ2 PLLP PLN PLP1 PLPP4 SLC30A8 SLC35A1 SLC35G5 SMIM1 SPOCK1 STX12 STX8 TM6SF2 TMEM128 TMEM14C TMEM242 TMEM254 TMEM51 TMEM72 TMEM86A TMEM86B TMEM97 TMUB2 TNF TNMD TRARG1 UPK1B VAMP3 VAMP4
Entrez ID		53345	23786
HPRD ID		12109	09822
Ensembl ID		ENSG00000213996	ENSG00000099968
Uniprot IDs		Q8N8A7 Q9BZW4	A0A087WTL4 A0A087WW80 A0A087WX97 A0A0A0MR90 A8K5Y4 B2RB43 B7Z238 B7Z737 E9PDD6 F6VJB4 Q86T62 Q9BXK5
PDB IDs			2IPD
Enriched GO Terms of Interacting Partners?
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