PITX2 and SLAMF7

		PITX2	SLAMF7
Description		paired like homeodomain 2	SLAM family member 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Identical Protein Binding
	Biological Process	Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Anatomical Structure Morphogenesis Hair Cell Differentiation Deltoid Tuberosity Development Odontogenesis Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Embryonic Heart Tube Left/right Pattern Formation Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification	Adaptive Immune Response Cell Adhesion Natural Killer Cell Activation T Cell Activation Natural Killer Cell Mediated Cytotoxicity
Pathways		TFAP2 (AP-2) family regulates transcription of other transcription factors	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Elotuzumab
Diseases
GWAS		Appendicitis ( 30392061) Atrial fibrillation ( 28416818 28416822 29290336 30061737 29892015 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 33627673) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676 29531354) Ischemic stroke (cardioembolic) ( 27068588 26708676 29531354) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Sick sinus syndrome ( 33580673) Smoking status (heavy vs never) ( 26423011) Stroke ( 29531354) Stroke (ischemic) ( 23041239)	Blood protein levels ( 30072576 29875488 28240269) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233) Microalbuminuria ( 26631737) Multiple sclerosis ( 24076602)
Interacting Genes		37 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS SLAMF7 TEX37 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3	11 interacting genes: ADRA2A API5 CLK3 MAK PANK1 PITX2 SH2D1A SVIL THRSP TMOD4 TRIB2
Entrez ID		5308	57823
HPRD ID		03328	09432
Ensembl ID		ENSG00000164093	ENSG00000026751
Uniprot IDs		Q99697	B4DVL7 B4DW98 Q9NQ25
PDB IDs		2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?
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