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PIK3R2 and EPHA2
Number of citations of the paper that reports this interaction (PubMedID
7982920
)
37
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
PIK3R2
EPHA2
Description
phosphoinositide-3-kinase regulatory subunit 2
EPH receptor A2
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Phosphatidylinositol 3-kinase Complex
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Lamellipodium
Leading Edge Membrane
Lamellipodium Membrane
Ruffle Membrane
Neuron Projection
Receptor Complex
Tight Junction
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Virus Receptor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Cadherin Binding
Biological Process
Cellular Glucose Homeostasis
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Phosphatidylinositol 3-kinase Signaling
Protein Transport
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Phosphatidylinositol Phosphate Biosynthetic Process
Skeletal System Development
Vasculogenesis
Osteoblast Differentiation
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Lamellipodium Assembly
Notochord Formation
Cell Migration
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Neural Tube Development
Keratinocyte Differentiation
Osteoclast Differentiation
Negative Regulation Of Chemokine Production
Mammary Gland Epithelial Cell Proliferation
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Kinase Activity
Post-anal Tail Morphogenesis
Protein Kinase B Signaling
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Angiogenesis
CAMP Metabolic Process
Viral Entry Into Host Cell
Bone Remodeling
Ephrin Receptor Signaling Pathway
Axial Mesoderm Formation
Cell Motility
Defense Response To Gram-positive Bacterium
Negative Regulation Of Protein Kinase B Signaling
Notochord Cell Development
Cell Chemotaxis
Branching Involved In Mammary Gland Duct Morphogenesis
Lens Fiber Cell Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Protein Localization To Plasma Membrane
Activation Of GTPase Activity
Negative Regulation Of Lymphangiogenesis
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Bicellular Tight Junction Assembly
Pericyte Cell Differentiation
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOG GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Drugs
Isoprenaline
SF1126
Dasatinib
Phosphoaminophosphonic Acid-Adenylate Ester
Regorafenib
Fostamatinib
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Alanine aminotransferase levels (
33547301
34315874
33339817
)
Aspartate aminotransferase levels (
33547301
34315874
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Interacting Genes
59 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
87 interacting genes:
ABCB5
ACP1
AKT1
ANXA1
APP
ARAF
ARNT
AURKA
BECN1
CBL
CBLC
CCND2
CD44
CDC42
CDH5
CDK17
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLDN4
DUSP14
DUSP18
DUSP19
DUSP26
DUSP29
EFNA1
EFNA2
EFNA3
EFNA4
EFNA5
EGFR
ERBB2
FGFR4
FZR1
GATAD1
GIGYF2
GLIS2
GRB2
GRK2
GRM1
HGF
HIF1A
ILKAP
KDELR2
KPNA3
LATS2
LSM7
MAP2K5
MAP2K6
MAPK14
MDM4
MET
MSH2
MYC
NF1
NF2
NFIC
NUDT9
PDGFRA
PIK3R1
PIK3R2
PPM1L
PSME2
PTEN
PTK2
PTPN11
PTPN7
PTPRR
RAF1
RASA1
RASSF1
RBL1
RELA
SHC1
SLA
STK11
STYX
TEAD2
TIAM1
TNFAIP1
TNFRSF8
TP53
TPTE
TPTE2
UBE4A
Entrez ID
5296
1969
HPRD ID
04404
01494
Ensembl ID
ENSG00000105647
ENSG00000142627
Uniprot IDs
O00459
A0A024QZA8
P29317
PDB IDs
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
1MQB
2E8N
2K9Y
2KSO
2X10
2X11
3C8X
3CZU
3FL7
3HEI
3HPN
3KKA
3MBW
3MX0
3SKJ
4P2K
4PDO
4TRL
5EK7
5I9U
5I9V
5I9W
5I9X
5I9Y
5I9Z
5IA0
5IA1
5IA2
5IA3
5IA4
5IA5
5NJZ
5NK0
5NK1
5NK2
5NK3
5NK4
5NK5
5NK6
5NK7
5NK8
5NK9
5NKA
5NKB
5NKC
5NKD
5NKE
5NKF
5NKG
5NKH
5NKI
5NZ9
6B9L
6F7M
6F7N
6FNF
6FNG
6FNH
6HES
6HET
6HEU
6HEV
6HEW
6HEX
6HEY
6NJZ
6NK0
6NK1
6NK2
6NKP
6Q7B
6Q7C
6Q7D
6Q7E
6Q7F
6Q7G
6RW2
7B7N
7CZE
7CZF
7KJA
7KJB
7KJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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