ATP6V0C and CLEC17A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ATP6V0C	CLEC17A
Description		ATPase H+ transporting V0 subunit c	C-type lectin domain containing 17A
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Azurophil Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Mannose Binding Identical Protein Binding Fucose Binding Metal Ion Binding
	Biological Process	ATP Synthesis Coupled Proton Transport Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases
GWAS			Iris color (L* coordinate) ( 30895295) Low density lipoprotein cholesterol levels ( 33339817) Response to antidepressants (symptom improvement) ( 29160301) Total cholesterol levels ( 33339817)
Interacting Genes		53 interacting genes: AQP6 ARF6 ASGR2 CD53 CD69 CD79A CERS2 CLEC14A CLEC17A CLEC2D CLIC1 CPLX4 CREB3 DNAJC1 DRD2 EDA EDA2R ERBB2 ERH EVI2A FAM210B FFAR2 GPR152 GPR25 GPR42 HSD17B13 HTR2C KLRC1 LMNA LRRC25 MARK3 MCEMP1 MDFI MSR1 NIPAL3 OPRM1 PDCD1LG2 PI16 PSMA3 RETREG3 SCN3B SLC35E3 SLC7A1 SMIM3 SPACA1 SSMEM1 STOM SUSD3 TMEM139 TMEM31 TMEM9 VSIR ZCCHC12	21 interacting genes: ASGR2 ATP6V0C CLDN8 CTXN3 CXCL9 FAM3C GPR152 IGFBP5 NCK2 NINJ2 OLFM4 PELI1 PELI2 RPRM SEC23A SMIM3 TM4SF4 TMEM140 TMEM201 TMEM218 UPK2
Entrez ID		527	388512
HPRD ID		00162	16993
Ensembl ID		ENSG00000185883	ENSG00000187912
Uniprot IDs		P27449	Q6ZS10
PDB IDs		6WLW 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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