PGM1 and USP4

Number of citations of the paper that reports this interaction (PubMedID 23022198)
7

Data Source:
BioGRID (two hybrid)

		PGM1	USP4
Description		phosphoglucomutase 1	ubiquitin specific peptidase 4
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane
	Molecular Function	Magnesium Ion Binding Phosphoglucomutase Activity Protein Binding	Thiol-dependent Deubiquitinase Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface
Pathways		Glycogen synthesis Defective PGM1 causes PGM1-CDG (CDG1t) Neutrophil degranulation	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs		Alpha-D-Glucose 1,6-Bisphosphate Alpha-D-Glucose-1-Phosphate-6-Vanadate
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Blood protein levels ( 29875488) Type 1 diabetes ( 32005708 19430480 33830302 34012112 34127860) Type 2 diabetes ( 32499647)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		19 interacting genes: APP CHAF1B DNAJB6 ENO3 HSPB2 KIF1B LINC01554 NLRP3 OGT PAXIP1 PEA15 POT1 S100A1 S100B TERF1 TERF2IP TINF2 USP4 XRN2	50 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Entrez ID		5236	7375
HPRD ID		01389	04598
Ensembl ID		ENSG00000079739	ENSG00000114316
Uniprot IDs		B4DDQ8 B7Z6C2 P36871	A0A024R2W0 A0A024R2X6 A1LPW7 Q08AK7 Q13107
PDB IDs		5EPC 5F9C 5HSH 5JN5 5TR2 5VBI 5VEC 5VG7 5VIN 6SNO 6SNP 6SNQ 6UIQ 6UO6	2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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