PDZK1 and FARP2

Number of citations of the paper that reports this interaction (PubMedID 14531806)
46

Data Source:
BioGRID (two hybrid, pull down)

		PDZK1	FARP2
Description		PDZ domain containing 1	FERM, ARH/RhoGEF and pleckstrin domain protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton
	Molecular Function	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding	Guanyl-nucleotide Exchange Factor Activity Cytoskeletal Protein Binding
	Biological Process	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Cell Adhesion Neuron Remodeling Rac Protein Signal Transduction Hair Cycle Process Osteoclast Differentiation Actin Cytoskeleton Reorganization Regulation Of Integrin Activation Regulation Of Catalytic Activity Semaphorin-plexin Signaling Pathway Podosome Assembly
Pathways			SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RAC1 GTPase cycle
Drugs
Diseases
GWAS		Contrast sensitivity ( 24152035) Gout ( 33832965 32238385) Serum uric acid levels ( 30993211) Urate levels ( 31985003 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Chronic lymphocytic leukemia ( 28165464 23770605) Copper levels ( 26025379) Disability (impaired activities of daily living) ( 31707593) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Neutrophil percentage of granulocytes ( 27863252) Prostate cancer ( 23535732) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549 32154731) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		31 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	4 interacting genes: PDZK1 SRC UBE2G2 YWHAG
Entrez ID		5174	9855
HPRD ID		04829	16885
Ensembl ID		ENSG00000174827	ENSG00000006607
Uniprot IDs		Q5T2W1	O94887
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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