YPEL5 and SHC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		YPEL5	SHC3
Description		yippee like 5	SHC adaptor protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Centrosome Midbody Mitotic Spindle Pole Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cellular_component Cytosol Plasma Membrane
	Molecular Function	Protein Binding Metal Ion Binding	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Cell Population Proliferation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Intracellular Signal Transduction
Pathways		Neutrophil degranulation	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		11 interacting genes: CTDSP1 DDIT4L FBXO7 GSC2 MAPKBP1 PFDN5 PLAGL2 PSMA1 SHC3 TRAF5 ZNF655	58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12
Entrez ID		51646	53358
HPRD ID		18312	12005
Ensembl ID		ENSG00000119801	ENSG00000148082
Uniprot IDs		P62699	Q92529
PDB IDs
Enriched GO Terms of Interacting Partners?
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