PPIL1 and COL17A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PPIL1	COL17A1
Description		peptidylprolyl isomerase like 1	collagen type XVII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Disordered Domain Specific Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Organization Hemidesmosome Assembly
Pathways		mRNA Splicing - Major Pathway	Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576 29875488) Heart rate ( 28610988) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Resting heart rate ( 27798624) Weight ( 28552196)	Cardiac hypertrophy ( 21348951)
Interacting Genes		25 interacting genes: COL17A1 CPSF6 DDIT4L GADD45G HNRNPA1 HNRNPUL1 KPRP LHX2 LNX2 N4BP2L2 POU6F2 PPP1R8 PRR22 PRR35 RBM42 RIMBP3 SF3B3 SNW1 SPDYE4 SRPK1 SRPK2 TCF4 THOC5 UFL1 WDR77	18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN
Entrez ID		51645	1308
HPRD ID		03194	00223
Ensembl ID		ENSG00000137168	ENSG00000065618
Uniprot IDs		A0A024RCX8 Q9Y3C6	Q9UMD9
PDB IDs		1XWN 2K7N 2X7K 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM
Enriched GO Terms of Interacting Partners?
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