PDHA1 and PDK1

Number of citations of the paper that reports this interaction (PubMedID 12676647)
164

Data Source:
HPRD (in vitro)

		PDHA1	PDK1
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehydrogenase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Protein Phosphorylation Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH	4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid
Diseases
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 28240269) Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		8 interacting genes: DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	15 interacting genes: AKT1 COL6A1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 USP4 XRCC6 YWHAQ
Entrez ID		5160	5163
HPRD ID		02420	03954
Ensembl ID		ENSG00000131828	ENSG00000152256
Uniprot IDs		A0A024RBX9 P08559	B7Z7N6 Q15118
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?
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