PDE6D and ARL3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid, in vivo, in vitro)

		PDE6D	ARL3
Description		phosphodiesterase 6D	ADP ribosylation factor like GTPase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Midbody Photoreceptor Connecting Cilium Extracellular Exosome
	Molecular Function	GTPase Inhibitor Activity Protein Binding Small GTPase Binding	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding GTPase Activating Protein Binding
	Biological Process	Visual Perception Negative Regulation Of Catalytic Activity Response To Stimulus	Mitotic Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Smoothened Signaling Pathway Small GTPase Mediated Signal Transduction Protein Transport Positive Regulation Of Microtubule Polymerization Intraciliary Transport Photoreceptor Cell Development Cilium Assembly Protein Localization To Cilium Protein Localization To Ciliary Membrane
Pathways		ARL13B-mediated ciliary trafficking of INPP5E RAS processing	Trafficking of myristoylated proteins to the cilium
Drugs			2-(N-morpholino)ethanesulfonic acid Guanosine-5'-Diphosphate
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 30487518) Mean arterial pressure (long-term average) ( 28348047) Prostate cancer ( 23535732) Pulse pressure ( 30487518) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 27922604) Systolic blood pressure ( 30487518) Systolic blood pressure (long-term average) ( 28348047) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	12 interacting genes: ARL2BP GOLGA4 LRIF1 PDE6D PTEN RP2 TBL1X TLE1 TP53 TUBA1A UBR1 UNC119
Entrez ID		5147	403
HPRD ID		04056	05260
Ensembl ID		ENSG00000156973	ENSG00000138175
Uniprot IDs		B8ZZK5 O43924 Q6IB24	P36405
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW
Enriched GO Terms of Interacting Partners?
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