MS4A4A and LPAR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MS4A4A	LPAR3
Description		membrane spanning 4-domains A4A	lysophosphatidic acid receptor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Plasma Membrane Raft	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Axon Synapse
	Molecular Function	Protein Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Protein Binding Phospholipid Binding Lipid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process		G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Regulation Of Metabolic Process Bleb Assembly Positive Regulation Of MAPK Cascade Positive Regulation Of Collateral Sprouting Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport
Pathways			G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 21460841) Alzheimer's disease in APOE e4- carriers ( 25778476) C-reactive protein levels ( 30388399) Cerebrospinal fluid sTREM-2 levels ( 31413141) Fibrinogen levels ( 28107422)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Dental caries ( 23064961) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		14 interacting genes: ATP6V0E1 CLDN19 CMTM7 LPAR3 MAL NRG1 PLP1 RPRM RUSF1 SEC22A SERTM1 TMEM14B TMUB2 UPK1B	58 interacting genes: APP AQP6 ARL13B ASZ1 BCL2L13 C16orf54 CD53 CD74 CD79A CLDN2 CLDN7 CLDN9 CLEC12B CPLX4 CREB3L1 CYB561 CYBRD1 EDA ERGIC3 FAM209A FAM210B FFAR2 FNDC9 GJB5 GNAI2 GORAB GPX8 JAGN1 KCNC1 KCNJ6 LEPROTL1 LHFPL5 LIME1 LMNA MFF MGST3 MRM1 MS4A4A NDUFAF2 OPRM1 PGRMC2 RELL2 RETREG3 SCN3B SGMS2 SHISAL1 SLC10A6 SLC16A2 SLC35C2 TFEC THAP4 TMEM14B TMEM237 TMEM31 TMEM41A TMEM52B TMEM70 TMEM79
Entrez ID		51338	23566
HPRD ID		08408	05486
Ensembl ID		ENSG00000110079	ENSG00000171517
Uniprot IDs		A0A384MDW1 Q4JF27 Q96JQ5	Q9UBY5
PDB IDs
Enriched GO Terms of Interacting Partners?
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