PCSK5 and FARS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PCSK5	FARS2
Description		proprotein convertase subtilisin/kexin type 5	phenylalanyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane Integral Component Of Golgi Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Peptide Binding	TRNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Limb Morphogenesis Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Regulation Of Lipoprotein Lipase Activity Cytokine Precursor Processing	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation TRNA Processing
Pathways		NGF processing Assembly of active LPL and LIPC lipase complexes	Mitochondrial tRNA aminoacylation
Drugs			Phenylalanine
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Apolipoprotein B levels ( 32203549) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 28552196 20881960 25282103 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Hypotension and cognitive impairment ( 31362389) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 29785010 31959993 30054594) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Low density lipoprotein cholesterol levels ( 32154731) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Waist-hip index ( 34021172) Weight ( 34074324)	Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Copper levels ( 26025379) Height ( 28552196) JT interval (sulfonylurea treatment interaction) ( 27958378) Metabolite levels ( 23823483) Obesity (early onset extreme) ( 23563609) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		72 interacting genes: ADAMTSL4 AMH APPBP2 ATN1 C17orf50 C22orf39 CACNA1A CCDC33 CLIC1 CREB5 CYSRT1 DBF4B DEK DOCK2 FAM86C1P FARS2 FRS3 GLRX3 GUCD1 HOXA1 HOXB9 INCA1 ITGA6 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 LCE1D LCE1F LCE2C LCE3C LCE3D MDFI MEOX2 NBPF19 NOTCH2NLA NR1D2 NR4A3 NUFIP2 OTX1 PCSK6 PLSCR4 PMCH POU4F2 PTPRM REN SH3GLB1 SHFL SMCP SPRY1 SSC4D STK16 TEKT4 TLE5 TRAF4 TRIB3 TRIM42 TRIP13 USP54 VGLL3 ZNF547 ZNF655 ZNF837	69 interacting genes: ADAMTSL4 AGTRAP AJUBA AP1B1 APPL1 BACH2 BAG4 BANP BEX5 CALCOCO2 CBY2 CCDC152 CDCA4 CMTM5 CYSRT1 DGAT2L6 DPH2 DVL3 FHL5 FKBP7 FSD2 GRB10 HIGD1C HMBOX1 HOMEZ IKZF3 ISY1-RAB43 KCNF1 KCTD17 KRT13 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-3 MAN1C1 MDFI MESD MID2 MKRN3 MORN3 NFKBID NOTCH2NLA PCSK5 PPP1R16B RCBTB2 RIMBP3C SPRY1 STX11 SYP TADA2A TEPSIN TFCP2 TPM2 TRAF2 TRIM27 TRIM54 TRIP6 YIF1A ZNF438 ZNF500 ZNF526 ZNF655 ZRANB1
Entrez ID		5125	10667
HPRD ID		08985	09946
Ensembl ID		ENSG00000099139	ENSG00000145982
Uniprot IDs		Q92824	O95363
PDB IDs			3CMQ 3HFV 3TEG 3TUP 5MGH 5MGU 5MGV 5MGW
Enriched GO Terms of Interacting Partners?
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