CHCHD2 and POLDIP2

Number of citations of the paper that reports this interaction (PubMedID 27499296)
99

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CHCHD2	POLDIP2
Description		coiled-coil-helix-coiled-coil-helix domain containing 2	DNA polymerase delta interacting protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space	Nucleus Mitochondrion Mitochondrial Matrix Plasma Membrane Cell-cell Junction Midbody Mitochondrial Nucleoid Mitotic Spindle
	Molecular Function	Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding	DNA Binding Protein Binding
	Biological Process	Mitochondrion Organization Cellular Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Hypoxia Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Negative Regulation Of Macroautophagy Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Focal Adhesion Assembly Mitochondrion Morphogenesis Error-free Translesion Synthesis Mitotic Spindle Assembly Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Actin Filament Binding Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		Mitochondrial protein import
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Metabolite levels ( 23823483 31628463) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)
Interacting Genes		31 interacting genes: ADAMTSL4 ADRA2C CHCHD10 CRYBA1 CTAG1A CTAG1B CYSRT1 EHMT2 FBXO7 GOLGA2 IKZF3 INCA1 KRT31 KRT40 LHX4 MIF4GD OIP5 P4HB PBX4 PLEKHF2 POLDIP2 REL RNF144B TCF4 TRAF2 TREX1 TRIM42 TRIM54 TSC1 USP54 ZMYND12	20 interacting genes: AGTRAP ALAS1 APP ASCC2 CHCHD2 CPE DNAAF6 FBXO7 HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN PTEN REV1 SELENBP1 TAB1 TMEM97
Entrez ID		51142	26073
HPRD ID		09879	17874
Ensembl ID		ENSG00000106153	ENSG00000004142
Uniprot IDs		Q9Y6H1	B4DEM9 Q9Y2S7
PDB IDs			6Z9C
Enriched GO Terms of Interacting Partners?
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