COPS4 and COPS3

Number of citations of the paper that reports this interaction (PubMedID 11337588)
246

Data Source:
HPRD (in vivo, in vitro)

		COPS4	COPS3
Description		COP9 signalosome subunit 4	COP9 signalosome subunit 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Protein Binding
	Biological Process	Protein Deneddylation	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		24 interacting genes: BRME1 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS7B COPS8 CUL5 FOS GPS1 IKBKB IL1RN KRT19 MBIP PCDHB12 PEX14 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ	32 interacting genes: ARAF ARF4 C17orf75 CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53
Entrez ID		51138	8533
HPRD ID		09888	07262
Ensembl ID		ENSG00000138663	ENSG00000141030
Uniprot IDs		A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78	B4DN01 Q9UNS2
PDB IDs		4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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