PCM1 and TTC8

Number of citations of the paper that reports this interaction (PubMedID 14520415)
235

Data Source:
HPRD (in vivo)

		PCM1	TTC8
Description		pericentriolar material 1	tetratricopeptide repeat domain 8
Image
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Centriole Cytosol Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Apical Part Of Cell Non-motile Cilium	Centrosome Cytosol Cilium Photoreceptor Connecting Cilium BBSome Ciliary Basal Body Ciliary Membrane Non-motile Cilium
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cytoplasmic Microtubule Organization Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Non-motile Cilium Assembly	Establishment Of Planar Polarity Axon Guidance Sensory Perception Of Smell Protein Transport Olfactory Bulb Development Regulation Of Protein Localization Negative Regulation Of GTPase Activity Multicellular Organism Growth Establishment Of Epithelial Cell Apical/basal Polarity Fat Cell Differentiation Establishment Of Anatomical Structure Orientation Sensory Processing Regulation Of Stress Fiber Assembly Inner Ear Receptor Cell Stereocilium Organization Camera-type Eye Photoreceptor Cell Differentiation Cilium Assembly Renal Tubule Development Protein Localization To Plasma Membrane Multi-ciliated Epithelial Cell Differentiation Non-motile Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	Copper levels ( 26025379) Limited cutaneous systemic scleroderma ( 29293537) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		47 interacting genes: ABI1 ABI2 AKAP9 BBS4 CASK CCDC172 CCHCR1 CDC42 CEP72 CYTH4 DDIT3 DDX23 DPYSL2 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FGF20 FXR2 GABARAP GOLGA2 HAP1 ING5 KLC1 KLC4 KRT15 KRT19 KRT24 MCRS1 NECAB2 PCNT PDGFRL PRC1 PRKCI PXN RALBP1 RBM5 RINT1 RPA2 TFIP11 TNFRSF10B TTC8 WASHC3 YWHAE YWHAQ	2 interacting genes: PCM1 PTPN21
Entrez ID		5108	123016
HPRD ID		02624	10484
Ensembl ID		ENSG00000078674	ENSG00000165533
Uniprot IDs		A2RUU9 B9EIS5 Q15154	A0A0C4DGH8 A0A0C4DGX9 A0A0C4DGY3 B3KSL8 Q86U25 Q8TAM2
PDB IDs		6HYL 6HYM	6XT9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?