TMX2 and PTAFR

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		TMX2	PTAFR
Description		thioredoxin related transmembrane protein 2	platelet activating factor receptor
Image
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Membrane-bounded Organelle Mitochondria-associated Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Secretory Granule Membrane Tertiary Granule Membrane
	Molecular Function	Protein Binding Disulfide Oxidoreductase Activity Identical Protein Binding	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity Mitogen-activated Protein Kinase Binding
	Biological Process	Brain Development	Positive Regulation Of Cellular Extravasation Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Parturition Response To Symbiotic Bacterium Positive Regulation Of Phospholipase C Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Neutrophil Degranulation Transcytosis Positive Regulation Of Translation Negative Regulation Of Blood Pressure Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inositol Phosphate Biosynthetic Process Cellular Response To Gravity Cellular Response To CAMP Cellular Response To Fatty Acid Response To Dexamethasone Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Transcytosis Positive Regulation Of Maternal Process Involved In Parturition Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Cellular Response To 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
Pathways			Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling
Drugs			Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656)	Blond vs. brown/black hair color ( 30531825)
Interacting Genes		163 interacting genes: AGPAT3 AGPAT4 AGPAT5 AIG1 AQP6 ARV1 ASGR1 ASPH ATXN1 BDKRB1 BET1 BNIP1 BNIP2 BNIP3 BRICD5 BTN2A2 C2CD2L C3orf52 CCDC167 CCL2 CD81 CDIPT CDS2 CMTM7 COL8A2 COMMD8 COX20 CTSA CTXN3 CXCL16 CXorf66 CYBC1 CYP4F2 DERL1 DGAT2L6 EMD EMP3 F2RL1 FA2H FAM177A1 FAM241B FAM3C FAXDC2 FDFT1 FUNDC2 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 HACD2 HHATL HMOX2 HSD17B11 HSD17B13 HTATIP2 IER3 IER3IP1 IGFBP5 INSIG2 ITGAM LEPROT LEPROTL1 LHFPL5 LRAT MALL MFF MFSD14B MGLL MGST3 MIP MLN MS4A1 MTNR1A NAT8 NDUFA3 NINJ2 NRM NSDHL NSG1 ORMDL2 OTULINL PAEP PEDS1-UBE2V1 PEX16 PKMYT1 PLP2 PNLIPRP1 PRAF2 PRB1 PTAFR PTPN9 RABAC1 REEP2 REEP4 RFT1 RNF24 RTP2 RUSF1 SACM1L SCAMP5 SCD SELENOK SERF1A SERF1B SERP2 SFT2D1 SFXN1 SFXN3 SLC22A18 SLC22A2 SLC29A2 SLC35A1 SMAGP SMCO4 SMIM1 STATH STX12 STX3 STX7 THBD THSD7B TMBIM6 TMEM115 TMEM120A TMEM120B TMEM121 TMEM128 TMEM140 TMEM14B TMEM14C TMEM176A TMEM201 TMEM203 TMEM208 TMEM222 TMEM239 TMEM254 TMEM31 TMEM50B TMEM51 TMEM65 TMEM71 TMEM86B TMEM97 TPRG1 TRAM1L1 TREX1 TSNARE1 TSPAN2 TVP23B UBE2J1 UNC93A VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB WFDC2 YIF1A YIPF1 YIPF2 YIPF6	19 interacting genes: ARR3 ARRB2 CALM1 GORAB GRIN1 GTPBP3 IFITM3 MBP MFSD3 PLLP PPM1J PRNP RGS4 RHBDD2 SERINC5 SPATA24 TMEM120A TMX2 TYK2
Entrez ID		51075	5724
HPRD ID		07159	01422
Ensembl ID		ENSG00000213593	ENSG00000169403
Uniprot IDs		Q9Y320	A8K7N8 P25105
PDB IDs		2DJ0	2B0X
Enriched GO Terms of Interacting Partners?
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