APIP and VPS25

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
HPRD (two hybrid)

		APIP	VPS25
Description		APAF1 interacting protein	vacuolar protein sorting 25 homolog
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GO Annotations	Cellular Component	Cytoplasm Cytosol	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Methylthioribulose 1-phosphate Dehydratase Activity	Structural Molecule Activity Protein Binding Protein Homodimerization Activity Protein N-terminus Binding
	Biological Process	Apoptotic Process L-methionine Salvage From S-adenosylmethionine L-methionine Salvage From Methylthioadenosine Negative Regulation Of Apoptotic Process Protein Homotetramerization Pyroptosis Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Pathways		Formation of apoptosome Methionine salvage pathway Regulation of the apoptosome activity	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010 33339817) Lung disease severity in cystic fibrosis ( 26417704) Prostate-specific antigen levels ( 28139693) Systemic lupus erythematosus ( 19838195)
Interacting Genes		19 interacting genes: APAF1 BAZ2B CFAP206 GORASP2 IMPDH2 LNX1 NIF3L1 NTAQ1 NUDT18 PDZD4 PPP1CC PSMA1 SDCBP SKP1 TNPO2 TSC22D4 VIM VPS25 ZBTB25	22 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 DCAKD GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 VPS36
Entrez ID		51074	84313
HPRD ID		14725	14396
Ensembl ID		ENSG00000149089	ENSG00000131475
Uniprot IDs		Q96GX9	A0A024R1X3 Q9BRG1
PDB IDs		4M6R	2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?
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