FIS1 and KMT2E

		FIS1	KMT2E
Description		fission, mitochondrial 1	lysine methyltransferase 2E (inactive)
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GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Cytosol Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Response To Muscle Activity Peroxisome Fission Response To Nutrient Levels Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Cellular Response To Glucose Stimulus Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Cellular Response To Toxic Substance Cellular Response To Peptide Response To Fluoride Negative Regulation Of ATP Metabolic Process Cellular Response To Thapsigargin Response To Flavonoid Response To Hypobaric Hypoxia Negative Regulation Of Fatty Acid Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Neutrophil Mediated Immunity DNA Methylation Chromatin Organization Cell Cycle Erythrocyte Differentiation Neutrophil Activation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation
Pathways		Class I peroxisomal membrane protein import	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 30891314)	Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		31 interacting genes: A2M ABHD6 APH1A BCAP31 CREB3 DNM1L EBP ERGIC3 FAM209A FAM210B FFAR2 JAGN1 KASH5 KCNJ6 KMT2E MARCHF5 MMGT1 NOS3 PIGP RNASEK SCN3B SLC10A6 SLC14A1 SLC22A1 SLC22A2 SPCS1 TBC1D15 TMEM14B TMPPE UBC VKORC1	12 interacting genes: ALKBH4 ASH2L ATP13A1 CDK1 CYP2C18 FIS1 IFT22 LAMTOR5 MAPRE2 NFE4 TRAPPC14 ZCWPW1
Entrez ID		51024	55904
HPRD ID		12352	10528
Ensembl ID		ENSG00000214253	ENSG00000005483
Uniprot IDs		Q9Y3D6	Q8IZD2
PDB IDs		1NZN 1PC2	2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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