FOXP3 and PRR20D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FOXP3	PRR20D
Description		forkhead box P3	proline rich 20D
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Homeostasis Negative Regulation Of Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment T Cell Mediated Immunity Tolerance Induction To Self Antigen Regulation Of T Cell Anergy Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Response To Radiation Response To Virus Gene Expression Establishment Of Endothelial Blood-brain Barrier Negative Regulation Of Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Defense Response To Virus Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Response To Rapamycin Negative Regulation Of T-helper 17 Cell Differentiation
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling
Drugs
Diseases
GWAS		Vitiligo ( 27723757)	Smoking initiation ( 33082346)
Interacting Genes		18 interacting genes: EP300 FOSB IKZF4 KAT8 KRTAP3-3 KRTAP6-2 KRTAP8-1 MDM2 NFAT5 NFATC2 NLK PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RUNX1	89 interacting genes: ABI2 ANKHD1 ARID5A ATXN1 BANP BEND2 BHLHE40 BICRAL C10orf55 C1orf94 C3orf36 CABP2 CCNK CDC37 CELF4 DAZAP2 DMRT3 DVL3 EIF4ENIF1 ESRP1 FAM168A FAM222B FAM9A FOXH1 FOXP3 GLIS2 GTF2A1 HIVEP1 HLX HYPK KRTAP19-1 KRTAP19-5 LASP1 MAGED1 MBNL3 NCK2 NFYC NOTCH3 NTAQ1 OXER1 PATZ1 PHF1 PITX1 POGZ POU2F1 POU6F2 PRR20A PRR20B PRR20C PRR20E PRR34 PRR35 PTTG2 RBM23 RBM42 RBPMS RBPMS2 RHOXF2 RIPPLY1 RNF4 ROR2 SAMD11 SH3RF1 SIAH1 SMAP1 SNRPB SNRPC SP4 SRPK2 TBX3 TBX6 TCF7L2 TFG THAP1 TIAL1 TLX3 TOLLIP TPRX1 TRIM35 VAC14 VENTX VEZF1 VPS37C YPEL3 ZBTB32 ZC3H10 ZCCHC14 ZNF385C ZNF683
Entrez ID		50943	729246
HPRD ID		02242	19670
Ensembl ID		ENSG00000049768	ENSG00000227151
Uniprot IDs		B7ZLG1 Q9BZS1	P86478 P86479 P86480 P86481 P86496
PDB IDs		3QRF 4WK8
Enriched GO Terms of Interacting Partners?
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