NSDHL and GPR35

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		NSDHL	GPR35
Description		NAD(P) dependent steroid dehydrogenase-like	G protein-coupled receptor 35
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	C-3 Sterol Dehydrogenase (C-4 Sterol Decarboxylase) Activity 3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Activity 3-beta-hydroxysteroid Dehydrogenase/C4-decarboxylase Activity 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) Activity 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) Activity	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Hair Follicle Development Cholesterol Biosynthetic Process Smoothened Signaling Pathway Cholesterol Metabolic Process Labyrinthine Layer Blood Vessel Development	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential
Pathways		Cholesterol biosynthesis	Class A/1 (Rhodopsin-like receptors)
Drugs		NADH	Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Glycated hemoglobin levels ( 34059833)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		5 interacting genes: DCC GPR35 RHBDD1 TMEM31 TMX2	59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		50814	2859
HPRD ID		02229	16003
Ensembl ID		ENSG00000147383	ENSG00000178623
Uniprot IDs		A0A384NPZ7 Q15738	A8K2J1 B2RA17 Q9HC97
PDB IDs		6JKG 6JKH
Enriched GO Terms of Interacting Partners?
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