DCAF8 and GSK3A

Number of citations of the paper that reports this interaction (PubMedID 30824926)
2

Data Source:
BioGRID (two hybrid)

		DCAF8	GSK3A
Description		DDB1 and CUL4 associated factor 8	glycogen synthase kinase 3 alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Axon Beta-catenin Destruction Complex Neuronal Cell Body Apical Dendrite Postsynapse Proximal Dendrite
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Kinase A Catalytic Subunit Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Protein Ubiquitination	Regulation Of Systemic Arterial Blood Pressure Cardiac Left Ventricle Morphogenesis Glycogen Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Protein Phosphorylation Signal Transduction Dopamine Receptor Signaling Pathway Nervous System Development Aging Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interleukin-3 Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Hypermethylation Of CpG Island Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Excitatory Postsynaptic Potential Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lithium Ion Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Amyloid-beta Formation Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Glycogen Synthase Activity, Transferring Glucose-1-phosphate Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Dendrite Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Glycogen (starch) Synthase Activity
Pathways		Neddylation	AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein
Drugs			Fostamatinib
Diseases
GWAS		Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)	Meat-related diet ( 32066663)
Interacting Genes		14 interacting genes: DDB1 GSK3A GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBPMS SUV39H1 THAP1 TNS2 TRIM54 WDR76	80 interacting genes: AKAP11 AKT1 ALKBH3 AP3D1 AURKAIP1 AXIN2 BCCIP BCL2L1 BCL3 BICD1 C11orf98 CCDC174 CHTOP CNTROB CREB1 CREM DCAF8 DCP1B DDI1 DEAF1 DNAJB1 DRC1 EBNA1BP2 EIF2B5 FAM193B FBXO42 GLI3 GOLGA6C GSKIP H2AZ2 HMBS HMGN1 HNRNPM HSF1 HSP90AA1 HSP90AB1 LDHA LRP6 LRRC37A2 LRSAM1 MAEA MAPT MCL1 MPHOSPH9 MTCH1 MYC MYL12A NBR1 OGT PRKACA PRKCA PRKCB PRKCD PRKCG PRKCH PRKCZ PRKD3 PRKDC PSMD8 PTMA PXN RICTOR RPL15 RPL19 RPL29 RPS15 RPS19 RUNX1 SBNO1 SGK1 SGK3 SMARCA5 SMG7 SPG21 STAT2 SUGP2 TTC16 UBTF VCPIP1 YWHAG
Entrez ID		50717	2931
HPRD ID		18300	06002
Ensembl ID		ENSG00000132716	ENSG00000105723
Uniprot IDs		B7Z8C9 Q5TAQ9	A0A024R0L5 P49840
PDB IDs		3I8E	2DFM
Enriched GO Terms of Interacting Partners?
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