ALDH7A1 and LCN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALDH7A1	LCN2
Description		aldehyde dehydrogenase 7 family member A1	lipocalin 2
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Specific Granule Lumen Extracellular Exosome
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity L-aminoadipate-semialdehyde Dehydrogenase Activity Protein Binding Betaine-aldehyde Dehydrogenase Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Enterobactin Binding
	Biological Process	Cellular Aldehyde Metabolic Process Sensory Perception Of Sound Glycine Betaine Biosynthetic Process From Choline Choline Catabolic Process	Apoptotic Process Acute-phase Response Response To Xenobiotic Stimulus Response To Herbicide Response To Blue Light Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Oxygen-glucose Deprivation Sequestering Of Iron Ion Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Choline catabolism Lysine catabolism	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs		NADH Artenimol	Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS		Colorectal cancer ( 30529582) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Metabolite levels ( 23823483) Osteoporosis ( 20072603)
Interacting Genes		6 interacting genes: APP EPS8 LCN2 MYG1 OGT RECQL5	62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF C20orf85 CAMLG CCNC CDSN CHIC2 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1
Entrez ID		501	3934
HPRD ID		00124	02551
Ensembl ID		ENSG00000164904	ENSG00000148346
Uniprot IDs		P49419	P80188
PDB IDs		2J6L 4X0T 4X0U 4ZUK 4ZUL 4ZVW 4ZVX 4ZVY 6O4B 6O4C 6O4D 6O4E 6O4F 6O4G 6O4H 6O4I 6O4K 6O4L 6U2X 6V0Z	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA
Enriched GO Terms of Interacting Partners?
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