ORC2 and RFWD3

Number of citations of the paper that reports this interaction (PubMedID 33044890)
1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ORC2	RFWD3
Description		origin recognition complex subunit 2	ring finger and WD repeat domain 3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	DNA Replication Origin Binding Protein Binding	P53 Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Initiation	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Chromosome Breakage Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)	Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 28604728 28604732 23666239)
Interacting Genes		31 interacting genes: BCS1L CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RFWD3 RIPPLY3 RPA1 RPA2 SHANK2 XRCC5	15 interacting genes: APP ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		4999	55159
HPRD ID		03112	07678
Ensembl ID		ENSG00000115942	ENSG00000168411
Uniprot IDs		A0A024R411 Q13416	Q6PCD5
PDB IDs		5C8H 5UJ8 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS	6CVZ
Enriched GO Terms of Interacting Partners?
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