OPRD1 and SLC13A4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OPRD1	SLC13A4
Description		opioid receptor delta 1	solute carrier family 13 member 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Intrinsic Component Of Plasma Membrane Dendrite Membrane Neuron Projection Axon Terminus Membrane Raft Spine Apparatus Neuronal Dense Core Vesicle Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding G Protein-coupled Enkephalin Receptor Activity Peptide Binding Neuropeptide Binding	Protein Binding Sodium:sulfate Symporter Activity
	Biological Process	Immune Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance	Sodium Ion Transport Sulfate Transport Anion Transmembrane Transport Sulfate Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling	Sodium-coupled sulphate, di- and tri-carboxylate transporters
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases
GWAS		Tourette syndrome ( 30818990)	Alcoholic chronic pancreatitis ( 28754779) Diverticular disease ( 30177863)
Interacting Genes		22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237	26 interacting genes: ACKR2 CBLIF CD79A CDS1 CERS4 DEFB108B DERL3 EFNA5 EOGT ERMP1 FCER1G GJA5 GPR152 GPR61 IER3 IGFBP5 MS4A13 OPRD1 OTOP3 SLC35A4 SLC35E4 SLC38A1 SLC41A1 TMEM147 TMEM60 TRARG1
Entrez ID		4985	26266
HPRD ID		01308	10372
Ensembl ID		ENSG00000116329	ENSG00000164707
Uniprot IDs		P41143	Q59HF0 Q9UKG4
PDB IDs		1OZC 2IQM 4N6H 4RWA 4RWD 6PT2 6PT3
Enriched GO Terms of Interacting Partners?
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