NPM1 and CENPW

Number of citations of the paper that reports this interaction (PubMedID 28920929)
5

Data Source:
BioGRID (unspecified method)

		NPM1	CENPW
Description		nucleophosmin 1	centromere protein W
Image			No pdb structure
GO Annotations	Cellular Component	Granular Component Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Large Ribosomal Subunit Small Ribosomal Subunit Membrane Nuclear Speck Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex	Chromosome, Centromeric Region Kinetochore Nucleoplasm Nucleolus Nuclear Matrix
	Molecular Function	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding RRNA Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Protein N-terminus Binding NF-kappaB Binding Unfolded Protein Binding DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Regulation Of Cell Growth DNA Repair Nucleosome Assembly Chromatin Remodeling RRNA Export From Nucleus Cell Volume Homeostasis Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Cell Aging Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Positive Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Positive Regulation Of Protein Ubiquitination Regulation Of Endodeoxyribonuclease Activity Cellular Response To UV Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Localization To Nucleolus	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly
Pathways		Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs		Artenimol
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Multisite chronic pain ( 33830993) Subcortical volume (MOSTest) ( 32665545)	Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Caffeine consumption from coffee or tea ( 33287642) Coronary artery disease ( 29212778) Cortical surface area (global PC1) ( 32198502) Cortical surface area (visual PC2) ( 32198502) Diastolic blood pressure ( 27841878) Feeling nervous ( 29500382) Food addiction ( 27106561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intracranial volume ( 22504418) Intraocular pressure ( 29617998) Kidney volume ( 34128465) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 27182965 28196072) Menarche (age at onset) ( 27182965 25231870) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Neuroticism ( 29255261) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pulse pressure ( 27841878) QT interval ( 29213071) Subcortical brain region volumes ( 25607358) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Type 1 diabetes ( 30659077 30572963) Type 2 diabetes ( 30297969 32499647 28869590) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		65 interacting genes: ABCC1 ACY1 ALK APP ARF1 CACYBP CCR1 CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 FBXW7 GADD45A GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NOP2 NPM2 OGT PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIL1 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 TRIM28 UBC UQCRH XPO1 YY1	6 interacting genes: BTRC CENPB CENPT CUL1 H3C1 NPM1
Entrez ID		4869	387103
HPRD ID		01246	16660
Ensembl ID		ENSG00000181163	ENSG00000203760
Uniprot IDs		A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 P06748	A0A0A0MRK5 Q5EE01
PDB IDs		2LLH 2P1B 2VXD 5EHD
Enriched GO Terms of Interacting Partners?
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