NPC1 and MC4R

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		NPC1	MC4R
Description		NPC intracellular cholesterol transporter 1	melanocortin 4 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Late Endosome Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Integral Component Of Lysosomal Membrane	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Sterol Transporter Activity Cholesterol Binding Signaling Receptor Activity	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding
	Biological Process	Protein Glycosylation Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Cholesterol Metabolic Process Bile Acid Metabolic Process Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Macroautophagy Cholesterol Transport Membrane Raft Organization Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Response To Cadmium Ion Viral Entry Into Host Cell Negative Regulation Of Cell Death Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Bone Resorption Regulation Of Eating Behavior Response To Melanocyte-stimulating Hormone Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior
Pathways		LDL clearance	Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Bremelanotide Setmelanotide
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Body size at age 10 ( 32376654) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Poultry consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Walking pace ( 33128006) White blood cell count ( 27863252)	Adult body size ( 32376654) Antipsychotic drug-induced weight gain ( 22566560) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 28552196 29381148 24064335 23563607 26426971 19079260 19079261 26961502 24348519 23669352 24861553 18454148 31453325 28892062 25673413 20935630 29273807 28448500 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 33045005 26604143) Childhood onset type 2 diabetes ( 33479058) Cobalt levels ( 26025379) Coffee consumption ( 31046077) Coffee consumption (cups per day) ( 31837886) Coronary artery disease ( 26343387 33020668) Daytime sleep phenotypes ( 27126917) Dentures ( 31235808) Diastolic blood pressure ( 27841878) Fat body mass ( 24064335) Fatty acid desaturase activity (serum) ( 30453627) Femoral neck bone mineral density ( 30172743) Free thyroxine concentration ( 30367059) Fruit consumption ( 32066663) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference ( 28552196 31453325 25673412) Hip circumference variance ( 31453325) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Leg lean mass (fat adjusted) ( 32719433) Metabolic syndrome ( 31589552) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 22013104) Systolic blood pressure ( 30224653) Total body bone mineral density ( 30172743) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 22885922 24509480 30054458 30297969 32499647 30718926 28869590) Ulna and radius bone mineral density ( 30172743) Urate levels ( 31578528 23263486) Waist circumference ( 28552196 19557197 31453325 25673412) Waist circumference and related phenotypes ( 18454146) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Weight ( 19079260)
Interacting Genes		6 interacting genes: BUD31 FURIN GPR35 MC4R MTDH VPS4A	20 interacting genes: AGRP AIG1 ASIP ATP6V0E2 ATRNL1 CD81 GRK2 IL1RAP MAL MC1R NPC1 NPY PDIA6 PLLP POMC PRKACA TMEM19 TMEM94 TSPAN3 YIPF3
Entrez ID		4864	4160
HPRD ID		09622	01116
Ensembl ID		ENSG00000141458	ENSG00000166603
Uniprot IDs		O15118	P32245
PDB IDs		3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V	2IQP 2IQR 2IQS 2IQU 2IQV 2IQW 6W25
Enriched GO Terms of Interacting Partners?
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