NPY and PMCH

Number of citations of the paper that reports this interaction (PubMedID 12106685)
6

Data Source:
HPRD (in vitro)

		NPY	PMCH
Description		neuropeptide Y	pro-melanin concentrating hormone
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Synapse Neuronal Dense Core Vesicle	Extracellular Region Nucleus Synapse
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Intestinal Epithelial Cell Differentiation	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Behavior Feeding Behavior Cell Differentiation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Phentermine 2-aminoisobutyric acid L-tyrosinamide
Diseases
GWAS		Adiponectin levels ( 33562295) Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Retinitis pigmentosa ( 33514863) Vitamin D levels ( 25208829)	Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		4852	5367
HPRD ID		01214	01459
Ensembl ID		ENSG00000122585	ENSG00000183395
Uniprot IDs		A4D158 P01303	P20382
PDB IDs		1QFA 1RON
Enriched GO Terms of Interacting Partners?
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