NOS1 and ADRA1D

Number of citations of the paper that reports this interaction (PubMedID 12184796)
7

Data Source:
HPRD (in vivo)

		NOS1	ADRA1D
Description		nitric oxide synthase 1	adrenoceptor alpha 1D
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Vesicle Membrane Postsynaptic Density Sarcoplasmic Reticulum Protein-containing Complex Sarcolemma Dendritic Spine Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Transmembrane Transporter Binding Cadmium Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	G Protein-coupled Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Muscle Contraction Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Xenobiotic Catabolic Process Vasodilation Negative Regulation Of Potassium Ion Transport Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Negative Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Retrograde Trans-synaptic Signaling By Nitric Oxide Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Neuron-glial Cell Signaling
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs		Citrulline Donepezil Ketamine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Formic acid 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide 1-hydroxy-2-isopropylguanidine N-omega-propyl-L-arginine 2-butyl-1-hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Flavin adenine dinucleotide Flavin mononucleotide N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Nicotinamide adenine dinucleotide phosphate S-Ethyl-N-Phenyl-Isothiourea [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium 5-N-Allyl-arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue	Amphetamine Midodrine Ranolazine Cabergoline Ropinirole Dapiprazole Amitriptyline Alfuzosin Norepinephrine Mirtazapine Phenylephrine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Mephentermine Methotrimeprazine Dextroamphetamine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Perospirone Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine
Diseases
GWAS		Anxiety ( 33859377) Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Depression ( 33859377) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)	Paneth cell defects in Crohn's disease ( 28352666) Preeclampsia ( 23551011) Sense of smell ( 26632684)
Interacting Genes		34 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM POLE PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23	8 interacting genes: ADRA1A FLNC LNX1 NOS1 SNTA1 SNTB1 SNTB2 SNTG1
Entrez ID		4842	146
HPRD ID		01226	00079
Ensembl ID		ENSG00000089250	ENSG00000171873
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	B0ZBE0 P25100
PDB IDs		4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC 6PNA 6PNB 6PNC 6PND 6PNE 6PNF 6PNG 6PNH 6PO5 6PO7 6PO8 6PO9 6POA 6POB 6POC 6POT
Enriched GO Terms of Interacting Partners?
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