NONO and ORC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NONO	ORC5
Description		non-POU domain containing octamer binding	origin recognition complex subunit 5
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Speck Paraspeckles RNA Polymerase II Transcription Regulator Complex	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding Identical Protein Binding	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Activation Of Innate Immune Response DNA Repair DNA Recombination Regulation Of Transcription, DNA-templated MRNA Processing Circadian Rhythm RNA Splicing Regulation Of Circadian Rhythm Innate Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		120 interacting genes: APBB1 AR BHLHE41 C11orf68 CA2 CD44 DANCR DDX6 DELEC1 ERCC6 ERG ESR1 EWSR1 FXR2 H3-4 IL7R IRAK3 LMO4 MAD1L1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN OGT ORC5 OTUD5 PIN1 PLEKHF2 POLR1H POLR2A PPP1CA PPP1CB PPP1CC PRKAA2 PRPF40A PSPC1 PTBP1 RNF8 SFPQ SMARCB1 SMARCC1 SMARCD1 SPI1 SUMO2 SYNPO TAF1 TCERG1 UBE2I USP11 WBP4	30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		4841	5001
HPRD ID		02098	09086
Ensembl ID		ENSG00000147140	ENSG00000164815
Uniprot IDs		A0A0S2Z4Z9 Q15233	A4D0P7 O43913 Q53FC8
PDB IDs		3SDE 5IFM	5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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