NME1 and TNPO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		NME1	TNPO2
Description		NME/NM23 nucleoside diphosphate kinase 1	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Centrosome Cytosol Intermediate Filament Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding RNA Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding	Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Metabolic Process Endocytosis Lactation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Hippocampus Development Cell Differentiation Response To Testosterone Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid Cellular Response To Xenobiotic Stimulus	Protein Import Into Nucleus
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 31043756) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		32 interacting genes: APEX1 AURKA CCND3 FBXO24 FXR1 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME2 NME3 NME4 NTAQ1 NUTF2 PID1 POLR1C PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3	53 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C12orf40 C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RAN RBM45 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 TRMT1 ZBTB32 ZC2HC1C
Entrez ID		4830	30000
HPRD ID		01131	04301
Ensembl ID		ENSG00000239672	ENSG00000105576
Uniprot IDs		A0A384MTW7 P15531	A0A024R7F7 O14787 Q05D48 Q4LE60
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4
Enriched GO Terms of Interacting Partners?
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