NHLH2 and KCNIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NHLH2	KCNIP1
Description		nescient helix-loop-helix 2	potassium voltage-gated channel interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Peripheral Nervous System Development Male Gonad Development Cell Migration In Hindbrain Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Ovulation Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Male Mating Behavior	Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport
Pathways			Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Electrocardiographic traits (multivariate) ( 32602732) Heart rate variability traits (SDNN) ( 28610988) Metabolite levels ( 23823483)	Acne (severe) ( 24927181) California verbal learning test score ( 31596458) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Normalized brain volume ( 19010793) Placental abruption ( 29884306) Pre-treatment viral load in HIV-1 infection ( 31219150) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		7 interacting genes: HES1 KCNIP1 LMO3 MYF5 TAF1D TCF12 TCF4	16 interacting genes: AMPD3 ASPH CIAO2A DAAM2 IL6ST KCND1 KCND2 KCND3 KCNIP2 LITAF NHLH2 NIF3L1 SOD3 SPP1 SPRED2 TBC1D25
Entrez ID		4808	30820
HPRD ID		01213	06879
Ensembl ID		ENSG00000177551	ENSG00000182132
Uniprot IDs		A1PLF1 Q02577	Q9NZI2
PDB IDs			1S1E 2I2R 2NZ0
Enriched GO Terms of Interacting Partners?
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