NFKB1 and IRF8

Number of citations of the paper that reports this interaction (PubMedID 8550813)
11

Data Source:
BioGRID (pull down)

		NFKB1	IRF8
Description		nuclear factor kappa B subunit 1	interferon regulatory factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex Secretory Granule Lumen Specific Granule Lumen	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Actinin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response JNK Cascade Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cholesterol Transport Negative Regulation Of Interleukin-12 Production Response To Muscle Stretch Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To DsRNA Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Virus Positive Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Angiotensin Positive Regulation Of MiRNA Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immune System Process Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Dendritic Cell Differentiation
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection	Interferon gamma signaling Interferon alpha/beta signaling
Drugs		Donepezil Pseudoephedrine Thalidomide Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Triflusal Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Basophil percentage of white cells ( 32888494) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Copper levels ( 26025379) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 29124443 30604766) Glomerular filtration rate (creatinine) ( 26831199) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Membranous nephropathy ( 32231244) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 27992413) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia (treatment resistant) ( 22479419) Serum total protein level ( 29403010) Serum uric acid levels ( 29124443) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 31672989 30247649) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 23128233) White blood cell count ( 32888494)	Aspartate aminotransferase levels ( 33547301) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Behcet's disease ( 33393726) Chronic lymphocytic leukemia ( 21131588 28165464 26956414 24292274 23770605) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Major depressive disorder x sex interaction ( 34099189) Monocyte count ( 23314186 28193307 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525953 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962 26663301 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)
Interacting Genes		106 interacting genes: ABCC2 APBB2 AR ATF3 BARD1 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 DNMT3L E2F1 ECSIT ELF1 ELF3 ESR1 ETS1 FBXO7 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PALS2 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TFAP2A TNFSF11 TNIP1 TNIP2 TP53BP1 TP53BP2 TRIP4 TSC22D3 TXN UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9	21 interacting genes: ATP2C2 COPS2 CST1 GAN IRF1 IRF2 IRF6 KIAA0513 MLC1 NFKB1 PLCG2 PPIG RELA SMURF2 SPI1 SPIRE2 TOP1 TRAF6 TRIM21 ZBTB17 ZDHHC7
Entrez ID		4790	3394
HPRD ID		01238	03336
Ensembl ID		ENSG00000109320	ENSG00000140968
Uniprot IDs		P19838	Q02556
PDB IDs		1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT
Enriched GO Terms of Interacting Partners?
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