NFE2L2 and REL

Number of citations of the paper that reports this interaction (PubMedID 32911434)
1

Data Source:
BioGRID (two hybrid, affinity chromatography technology, fluorescent resonance energy transfer)

		NFE2L2	REL
Description		nuclear factor, erythroid 2 like 2	REL proto-oncogene, NF-kB subunit
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Inflammatory Response Aging Response To Lithium Ion Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Glutathione Biosynthetic Process Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neuron Death
Pathways		ROS sensing by NFE2L2 ROS sensing by NFE2L2 Regulation of HMOX1 expression and activity Heme signaling	Activation of NF-kappaB in B cells
Drugs
Diseases
GWAS		Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 22412388 21102463) Erectile dysfunction ( 30583798) Hodgkin's lymphoma ( 21037568 24920014) Inflammatory bowel disease ( 23128233) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 22170493) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Ulcerative colitis ( 20228799)
Interacting Genes		80 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TNNT1 TRIM24 UBE2E2 WAC ZBTB24 ZNF396	326 interacting genes: A1CF AAAS ACBD4 ACOT12 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 AKT2 ALOX5 AQP1 AR ARFIP2 ARIH2 ARL16 ARMC7 ARNT2 ASAP3 ASMTL ATG9A ATP6V0D2 ATP6V1C2 ATPAF2 ATXN1 BANP BARHL2 BBS4 BCL2L15 BCL6 BID BMF C11orf68 C12orf75 C14orf119 C1orf109 C1orf50 C1orf56 C1orf74 C9orf72 CABP5 CACNA1S CALM1 CCNC CCNE1 CCNJL CDK18 CDKN1A CDKN2C CDKN2D CDR2L CENPX CEP19 CFAP206 CGGBP1 CHAF1A CHCHD2 CHIC2 CIB3 CINP CKS1B CLIC4 CLIP1 COL20A1 COL8A1 CPNE2 CPNE7 CPSF1 CSNK2A1 CTNNA3 CTNNBIP1 CXCL14 CYB5R2 DAAM2 DDX6 DEF6 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EHHADH EIF3A EIF3D EIF4A3 EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EMD EML2 EP300 EPHB6 EPM2AIP1 ESRRA ESRRG EXOC6B EXOSC1 EXOSC5 EXOSC8 FAAP20 FAM90A1 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FNDC3B FOXO4 FUT11 GADD45G GLRX3 GLYCTK GPKOW GRAP GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPF HNRNPLL HSD17B14 HSPA4 HSPA8 HSPB7 IL36RN KCTD6 KCTD7 KIAA0100 KLHL32 KLHL40 KLHL42 KRTAP9-4 L3MBTL2 LASP1 LENG1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MAPRE3 MB21D2 MBD3 MEMO1 MID2 MIEN1 MIPOL1 MLIP MMP2 MOGS MORF4L1 MORF4L2 MRPL10 MSRB3 MTPN MTURN MVP MXD1 MYO15B NABP1 NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFE2L2 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NMRK1 NOL9 NOTCH1 NOXA1 NR2C2AP NUCB1 NUDT10 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PADI3 PAK1IP1 PARVG PATE1 PCYT2 PELI2 PGAP6 PICK1 PIH1D2 PLCB4 PLEKHN1 PM20D2 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAA2 PRKAB2 PRKN PRPF31 PSMA1 PSMA4 PSMB8 PSORS1C2 PTGER3 PTK6 QARS1 R3HDM2 RAB11FIP5 RAB29 RAB41 RABIF RAD23A RAD51D RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 RTL8C RUNX1T1 S100A1 SAMD11 SAT1 SCNM1 SDCBP SEC14L4 SEC31A SEPTIN7 SERTAD2 SHC3 SIN3A SIX1 SLC39A13 SLC41A3 SLC6A12 SMG9 SNRNP25 SP1 SPATC1L SPG21 SPRY1 SRF STAMBPL1 STK16 SULT2B1 SUOX SZT2 TBC1D21 TBC1D22B TBP TCL1A TCP11L1 TDO2 THOC1 TLE5 TLX3 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRAPPC6A TRIM27 TRIM68 TRIM74 TSC22D3 TSEN15 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBASH3B UBE2D4 UBE2K UBE2Z UBXN7 VPS25 WNK3 YARS1 YJU2 ZBED8 ZBTB16 ZDHHC24 ZIC1 ZNF417 ZNF446 ZNF550 ZNF564 ZNF572 ZNF688 ZNF76 ZNF765
Entrez ID		4780	5966
HPRD ID		02732	01286
Ensembl ID		ENSG00000116044	ENSG00000162924
Uniprot IDs		Q16236	Q04864
PDB IDs		2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V
Enriched GO Terms of Interacting Partners?
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