ATP1A1 and FXYD2

Number of citations of the paper that reports this interaction (PubMedID 11832419)
20

Data Source:
HPRD (in vivo)

		ATP1A1	FXYD2
Description		ATPase Na+/K+ transporting subunit alpha 1	FXYD domain containing ion transport regulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Postsynaptic Density Intercalated Disc Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Axon Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Extracellular Exosome
	Molecular Function	P-type Sodium:potassium-exchanging Transporter Activity Protein Binding ATP Binding Phosphatase Activity ATP Hydrolysis Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity Chaperone Binding Steroid Hormone Binding	ATPase Activator Activity Sodium Channel Regulator Activity Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Response To Xenobiotic Stimulus Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Sodium Ion Export Across Plasma Membrane Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Potassium Ion Import Across Plasma Membrane	Sodium Ion Export Across Plasma Membrane Regulation Of Catalytic Activity Transmembrane Transport Positive Regulation Of P-type Sodium:potassium-exchanging Transporter Activity Potassium Ion Import Across Plasma Membrane Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate	Cyclothiazide Thimerosal
Diseases
GWAS		Coffee consumption ( 29367735) HDL cholesterol levels in HIV infection ( 33109212) Hip index ( 34021172) Macular thickness ( 30535121)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA SNAPIN TPT1 ZNRF1 ZNRF2	5 interacting genes: ATP1A1 ERGIC3 SGTA SLC22A1 SLC22A2
Entrez ID		476	486
HPRD ID		01662	03487
Ensembl ID		ENSG00000163399	ENSG00000137731
Uniprot IDs		P05023	P54710
PDB IDs			2MKV
Enriched GO Terms of Interacting Partners?
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