NCAM1 and NCAN

Number of citations of the paper that reports this interaction (PubMedID 29670169)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		NCAM1	NCAN
Description		neural cell adhesion molecule 1	neurocan
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Neuron Projection Collagen-containing Extracellular Matrix	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Virus Receptor Activity Protein Binding	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Cell Adhesion Viral Entry Into Host Cell Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway	Skeletal System Development Cell Adhesion Central Nervous System Development
Pathways		ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs			Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Cannabis use ( 30150663 27023175) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) Frailty index ( 34431594) Gastroesophageal reflux disease ( 33608531) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549 28869591) Irritable bowel syndrome ( 33608531) LDL levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (current vs never) ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878) Total cholesterol levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429)	Bipolar disorder ( 33263727 24618891 31043756 21353194) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 18193043 19060906 19060911 26780889) Nonalcoholic fatty liver disease ( 29385134) Plateletcrit ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656 23974872) Triglycerides ( 18193043 19060906 19060911)
Interacting Genes		19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	13 interacting genes: CCDC9 CNTN2 GDF1 HMGB1 L1CAM NCAM1 PTN PTPRF TNC TNR ZNF121 ZNF66 ZNF99
Entrez ID		4684	1463
HPRD ID		00301	02897
Ensembl ID		ENSG00000149294	ENSG00000130287
Uniprot IDs		A0A087WWD4 P13591	A0A024R7M3 O14594 Q4LE67
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN
Enriched GO Terms of Interacting Partners?
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