ATF3 and SUV39H1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		ATF3	SUV39H1
Description		activating transcription factor 3	SUV39H1 histone lysine methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus CHOP-ATF3 Complex	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Amino Acid Starvation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter In Response To Arsenic-containing Substance Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly Chromatin Organization RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency	PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression
Drugs		Pseudoephedrine
Diseases
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Cerebral amyloid deposition (PET imaging) ( 26252872) Coronary artery disease ( 29212778) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122)
Interacting Genes		50 interacting genes: APPL2 ATF2 ATF4 BATF BATF3 CEBPA CEBPE CEBPG CREB3 CREBBP CRK DBP DDIT3 DNMT3L DOK5 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUND KAT5 LRIF1 MAFF MAFG NEK2 NFE2L2 NFKB1 NUF2 PDX1 POLR3D SH2D1A SMAD3 SRA1 SS18L1 STAT1 STAT3 SUV39H1 TP53 TP73 UBE2I UBR1 UBR2 ZNF212	137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DDB1 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9
Entrez ID		467	6839
HPRD ID		04395	02221
Ensembl ID		ENSG00000162772	ENSG00000101945
Uniprot IDs		P18847	O43463
PDB IDs			3MTS
Enriched GO Terms of Interacting Partners?
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