PPP1R12A and SETD7

Number of citations of the paper that reports this interaction (PubMedID 21115810)
72

Data Source:
BioGRID (enzymatic study)

		PPP1R12A	SETD7
Description		protein phosphatase 1 regulatory subunit 12A	SET domain containing 7, histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Kinetochore Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Fiber PTW/PP1 Phosphatase Complex	Nucleoplasm Chromosome Nucleolus
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding	P53 Binding Chromatin Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Myosin-light-chain-phosphatase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Cellular Response To Xenobiotic Stimulus Regulation Of Establishment Of Endothelial Barrier	Chromatin Organization Cellular Response To DNA Damage Stimulus Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Response To Ethanol Positive Regulation Of Transcription, DNA-templated Regulation Of Histone H3-K9 Methylation Heterochromatin Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	PKMTs methylate histone lysines
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS		Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Ferritin levels ( 33491795) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)
Interacting Genes		14 interacting genes: ATXN10 CDKN3 DMPK IL16 ILF3 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG	31 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 OGT PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIL1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21
Entrez ID		4659	80854
HPRD ID		03606	16226
Ensembl ID		ENSG00000058272	ENSG00000145391
Uniprot IDs		B2RAH5 O14974	B5MCZ8 D6RJA0 Q8WTS6
PDB IDs		2KJY 5HUZ	1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT
Enriched GO Terms of Interacting Partners?
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