MYO1E and SMAD6

		MYO1E	SMAD6
Description		myosin IE	SMAD family member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microvillus Brush Border Adherens Junction Actin Cytoskeleton Myosin Complex Vesicle Clathrin-coated Endocytic Vesicle Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Protein-containing Complex Heteromeric SMAD Protein Complex
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity Phosphatidylinositol Binding Actin Filament Binding	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Vasculogenesis In Utero Embryonic Development Glomerular Filtration Nitrogen Compound Metabolic Process Endocytosis Actin Filament Organization Vesicle Transport Along Actin Filament Glomerular Basement Membrane Development Post-embryonic Hemopoiesis Platelet-derived Growth Factor Receptor Signaling Pathway Glomerular Visceral Epithelial Cell Development	Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Negative Regulation Of SMAD Protein Complex Assembly Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways			Signaling by BMP RUNX2 regulates bone development
Drugs		Imidazole
Diseases
GWAS		Adult body size ( 32376654) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Metabolite levels ( 22916037) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Serum metabolite levels (CMS) ( 31636271) Social communication problems ( 24047820)	Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lung cancer (smoking interaction) ( 24658283) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		5 interacting genes: ACTB CREBBP LTB4R2 SMAD6 SRPK2	24 interacting genes: ANXA2 BMPR1B CHRM5 HOXC8 MAP3K7 MAPK6 MYO1E PIGB PIK3R4 PPIB RAB11A RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1 UACA
Entrez ID		4643	4091
HPRD ID		03281	04240
Ensembl ID		ENSG00000157483	ENSG00000137834
Uniprot IDs		Q12965 Q4KMR3	O43541
PDB IDs
Enriched GO Terms of Interacting Partners?
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