GADD45B and MAP3K4

Number of citations of the paper that reports this interaction (PubMedID 9827804)
210

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GADD45B	MAP3K4
Description		growth arrest and DNA damage inducible beta	mitogen-activated protein kinase kinase kinase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade	MAPK Cascade Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping
Pathways
Drugs			Fostamatinib
Diseases
GWAS			Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)
Interacting Genes		16 interacting genes: CCNB1 CDK1 CDKN1A CNOT9 EFHC1 ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 NFIX PCNA PPARA PPARD PPARG	27 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 EPHB4 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ
Entrez ID		4616	4216
HPRD ID		05382	03886
Ensembl ID		ENSG00000099860	ENSG00000085511
Uniprot IDs		K7EPQ8 O75293	Q9P1M2 Q9Y6R4
PDB IDs
Enriched GO Terms of Interacting Partners?
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