ASPH and SF3A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ASPH	SF3A2
Description		aspartate beta-hydroxylase	splicing factor 3a subunit 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP Nuclear Speck U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Peptidyl-aspartic Acid 3-dioxygenase Activity	RNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Muscle Contraction Electron Transport Chain Peptidyl-aspartic Acid Hydroxylation Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing Positive Regulation Of Neuron Projection Development U2-type Prespliceosome Assembly
Pathways		Stimuli-sensing channels Ion homeostasis	mRNA Splicing - Major Pathway
Drugs		Aspartic acid	Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)	Adult body size ( 32376654) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Myocardial infarction ( 24916648) Pulse pressure ( 26390057)
Interacting Genes		74 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RAB2A RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 STAG1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16	21 interacting genes: APBB1 ASPH BAIAP2 BEND2 CDC42 GRB2 HTATSF1 LIN54 NCK2 OGT OSTF1 PRPF40A RETN SF3A1 SH3RF1 SMURF2 TCERG1 TFG TRIP10 VEZF1 YY1
Entrez ID		444	8175
HPRD ID		08996	02877
Ensembl ID		ENSG00000198363	ENSG00000104897
Uniprot IDs		B4DQ07 B7ZM96 Q12797	Q05DF2 Q15428
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9	5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6QX9 6Y53 6Y5Q 7ABG 7ABH 7ABI
Enriched GO Terms of Interacting Partners?
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