MNAT1 and NKX3-1

Number of citations of the paper that reports this interaction (PubMedID 18816836)
4

Data Source:
BioGRID (two hybrid)

		MNAT1	NKX3-1
Description		MNAT1 component of CDK activating kinase	NK3 homeobox 1
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GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleoplasm Transcription Factor TFIIH Holo Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Chromatin Nucleus Nucleoplasm Cytosol Site Of DNA Damage
	Molecular Function	Protein Binding Zinc Ion Binding Protein N-terminus Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association MADS Box Domain Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Repair Nucleotide-excision Repair Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Adult Heart Development Ventricular System Development Negative Regulation Of Apoptotic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Response To Calcium Ion Protein-containing Complex Assembly Negative Regulation Of DNA Helicase Activity	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Development Salivary Gland Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Differentiation Androgen Receptor Signaling Pathway Regulation Of Protein Localization Response To Testosterone Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Prostate cancer ( 32986714 34012061 26443449) Prostate-specific antigen levels ( 28139693) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		49 interacting genes: BEX3 BRCA1 CDK7 COPS6 DMAP1 E2F1 EEF1A1 ERCC2 ERCC3 ESR1 FOXP1 GOLGA2 GTF2E2 GTF2H1 GTF2H2 HMGB1 HPS6 LRIF1 MAGEC2 MAGEE2 MCM7 MDM4 MKRN3 MTA1 NKX3-1 POLR2A POU2F1 POU2F2 POU5F1 RB1 RBM48 RNF32 RNF41 RNF7 SUPT5H TET2 TP53 TRIM14 TRIM17 TRIM2 TRIM21 TRIM26 TRIM31 TRIM34 TRIM39 TRIM5 TRIM9 TRIML1 USP2	37 interacting genes: AEN CCT7 CD200R1L CENPX CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 MT-ND4 PEBP1 PTMS RABL6 RARG RHOXF2 RNF4 RPL37A RPSA SLC22A18 SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 TEX264 TOPORS TPT1 WDR77 ZNF417
Entrez ID		4331	4824
HPRD ID		04042	03620
Ensembl ID		ENSG00000020426	ENSG00000167034
Uniprot IDs		A0A024R669 A0A024R688 P51948	Q99801
PDB IDs		1G25 6NMI 6O9L 6O9M 6TUN 6XBZ 6XD3 7B5O 7B5Q	2L9R
Enriched GO Terms of Interacting Partners?
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