MMP14 and TGM2

Number of citations of the paper that reports this interaction (PubMedID 11278623)
64

Data Source:
BioGRID (enzymatic study)

		MMP14	TGM2
Description		matrix metallopeptidase 14	transglutaminase 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Chromatin Nucleus Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Extracellular Matrix Intrinsic Component Of Plasma Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding Metalloaminopeptidase Activity	Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Protein Domain Specific Binding Identical Protein Binding Protein-glutamine Glutaminase Activity Histone Serotonyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity
	Biological Process	Skeletal System Development Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Response To Organic Cyclic Compound Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Craniofacial Suture Morphogenesis Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Blood Vessel Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs		Marimastat	Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS		Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		36 interacting genes: ACAN ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CLDN1 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SPOCK1 SPOCK3 STOM TGM2 TIMP2 TIMP3 TIMP4 TMEM31 ZUP1	60 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 MMP14 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		4323	7052
HPRD ID		02856	01825
Ensembl ID		ENSG00000157227	ENSG00000198959
Uniprot IDs		P50281	B4DIT7 B4DTN7 P21980 V9HWG3
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1	1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB
Enriched GO Terms of Interacting Partners?
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