KMT2A and MTM1

Number of citations of the paper that reports this interaction (PubMedID 9537414)
60

Data Source:
BioGRID (pull down)

		KMT2A	MTM1
Description		lysine methyltransferase 2A	myotubularin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1 Complex	Ruffle Cytoplasm Late Endosome Cytosol Plasma Membrane Membrane Sarcomere Filopodium
	Molecular Function	Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Lysine-acetylated Histone Binding Protein-cysteine Methyltransferase Activity	Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Intermediate Filament Binding Phosphatidylinositol Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Apoptotic Process Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Histone H3-K4 Dimethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Protein-containing Complex Assembly Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Negative Regulation Of DNA Methylation Regulation Of Histone H3-K9 Acetylation	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Endosome To Lysosome Transport Protein Transport Peptidyl-tyrosine Dephosphorylation Regulation Of Vacuole Organization Intermediate Filament Organization Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Mitochondrion Distribution Mitochondrion Morphogenesis Negative Regulation Of Autophagosome Assembly
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		43 interacting genes: ASH2L AVP BMI1 CBX4 CKMT1A CREBBP CTNNB1 DCTN1 EXOSC5 FASLG H3-3A H3-4 H3C14 HCFC1 HCFC2 IL10RA INPPL1 INS KAT8 LAYN MCTS1 MEN1 MTM1 OXT PAF1 PAFAH1B2 PLAAT4 PLPP2 PLXNB1 PPIE PPP1R15A RBBP5 RDX RNF2 SBF1 SET SVIL TAF9 TASP1 TGFB2 TOP1 VWA5A WDR5	2 interacting genes: KMT2A MTMR12
Entrez ID		4297	4534
HPRD ID		01162	02331
Ensembl ID		ENSG00000118058	ENSG00000171100
Uniprot IDs		Q03164	A0A024RC06 Q13496
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R
Enriched GO Terms of Interacting Partners?
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