MEOX2 and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MEOX2	ALOX5
Description		mesenchyme homeobox 2	arachidonate 5-lipoxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Speck	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity
	Biological Process	Angiogenesis Somite Specification Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Skeletal Muscle Tissue Development Blood Circulation Positive Regulation Of Transcription By RNA Polymerase II Roof Of Mouth Development Limb Development Somite Development Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Hepoxilin Biosynthetic Process Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process
Pathways			Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs			Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Blood trace element (Zn levels) ( 23720494) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) HOMA-B (corrected for HOMA-IR) ( 30369944) Kidney function decline traits ( 25493955) Resting-state electroencephalogram vigilance ( 29703947) Sweet taste preference ( 32572145) Total intracranial volume ( 31530798) Triglyceride levels ( 32203549)	Alanine aminotransferase levels ( 33547301) Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		686 interacting genes: - - ABI2 ACBD4 ACOT12 ACSS1 ACTN4 ADAMTS12 ADGRF4 AGPAT1 AHCYL1 AHNAK AHSA2P AKT2 ALOX5 ALPP AMMECR1 AMOT ANKRD1 ANKRD12 ANKS1A ANP32B AP3M2 ARF6 ARHGEF7 ARIH2 ARL15 ARNT2 ARNTL2 ASB10 ATG12 ATG2A ATG5 ATG9A ATP5F1C ATP6V0D2 ATP6V1C2 ATPSCKMT ATXN1L AXIN1 B4GALT2 BANP BCL2L15 BEX1 BMP5 BNIP2 BOD1L2 BOLA2 BOLA2B BTBD3 BTK BTN1A1 BUD31 BYSL C10orf120 C10orf88 C11orf68 C1orf109 C1orf174 C1orf50 C2orf76 C9orf64 CACNA1S CAMK2B CAPRIN2 CARD9 CASP14 CBX2 CCDC102B CCDC103 CCDC13 CCDC196 CCDC6 CCL19 CCNC CCNYL1 CDC34 CDC7 CDCA7L CDH9 CDK3 CDK5 CDKN1A CDKN2D CEP57L1 CFAP206 CHD2 CHIC2 CHRD CHRNB4 CHRNG CHST15 CIAO1 CIAPIN1 CIB3 CINP CKS1B CLIC1 CLIP4 CLP1 CLVS2 CMTM5 CNTNAP2 COG7 COL9A2 COMP COX7A2 CPNE2 CPNE6 CPNE7 CPSF4 CRCT1 CSDC2 CSF2 CSH2 CSNK2A1 CT55 CTNNBL1 CUTC CXCL1 CXCL5 CXorf38 CXXC1 CYB5R2 CYCS CYP4F12 CYSRT1 DCX DEF8 DEFA5 DEPDC5 DESI1 DGCR6 DGCR8 DHPS DIRAS3 DMRT3 DNAAF11 DNAJC17 DNAJC22 DNMT3A DOCK8 DPF2 DPH3 DPM1 DRG1 DSCR8 DUS1L DYNC2I2 DYNLL2 DYNLT5 E2F8 EDF1 EFEMP1 EFEMP2 EFNA3 EIF1AD EIF3G EIF4A3 EIF5A EIF6 EMC7 EMD EME2 EPM2AIP1 ERF ESM1 ESR2 ESRRG ETV4 EXOSC5 FAAP20 FAM126A FAM13C FAM219B FAM221A FAM3A FAM53B FAM53C FAM71E2 FAM74A4 FANCC FANCG FBF1 FBLN1 FBLN5 FBXO39 FBXO44 FDX2 FGA FKBP6 FOSL2 FOXR1 FTL FUCA2 FUT11 FYN GABRB3 GAGE1 GCM2 GINS3 GJC1 GLO1 GMCL2 GMPR2 GNG11 GNG13 GOLGA8DP GOLGA8EP GOLGA8F GPANK1 GPATCH2L GPKOW GPSM3 GRIPAP1 GRN GSDMD GTPBP3 GUCD1 H1-7 HAT1 HDAC7 HDHD2 HELLS HEXIM2 HGF HK3 HLA-A HLA-DPB1 HMBOX1 HMGB3 HNRNPC HNRNPD HOOK1 HOOK3 HORMAD1 HOXB5 HOXC8 HP1BP3 HSD3B7 HSPA2 HTR1E IFIT2 IFNA14 IFNA6 IGF2BP3 IGFN1 IKZF1 IL1A ILF2 INPP1 INPP5J INSRR INTS10 IP6K2 IP6K3 IQGAP1 IRX6 ITGB3BP ITM2A JAM3 JPH1 KANK2 KAT5 KATNAL1 KBTBD7 KCNIP4 KCTD7 KCTD9 KDM6A KDM8 KIF5B KIF5C KIZ KLC4 KLHL32 KLHL38 KPRP KRT80 KRT81 KRT83 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KRTCAP3 KTN1 LAMTOR5 LARP1B LAT LCE1B LCE1D LCE1E LCE2A LCE4A LCN15 LEMD1 LIN37 LIPF LMO1 LNX1 LRRC18 LRRC27 LRRC52 LSM2 LUC7L2 LY6G6D MAB21L2 MACO1 MAGED1 MALSU1 MAPKBP1 MAPRE1 MAPRE3 MBD3 MCM7 MDFI METAP1 METTL17 METTL21A MFF MICOS10-NBL1 MID2 MKRN3 MLF1 MLLT6 MLX MMP25 MMP3 MOAP1 MOBP MORF4L1 MORF4L2 MORN3 MOS MPP1 MRFAP1L1 MSI2 MT-CO1 MT-ND1 MT1DP MTMR10 MVP MYBPC1 MYL7 MYO5B NAA10 NAA60 NALCN NBL1 NCALD NCK2 NCS1 NDUFA11 NDUFB2 NECTIN2 NEK6 NELL1 NFKBID NFYB NLGN3 NME7 NOL4 NOP10 NPIPB5 NR1D2 NSF NTAN1 NTF3 NTN4 ODAD4 ODF1 ODF2 ODF2L ODF4 OIT3 OLFM1 OLFM3 OR5K2 OR6B1 OSBPL1A OSGIN1 OSTF1 P4HA3 PACSIN2 PAGE2 PAGE5 PAK1IP1 PAM16 PARP3 PARVG PAX1 PAX3 PCDH9 PCSK5 PDE4C PDHA2 PDP1 PDS5A PELO PGBD1 PHF1 PICK1 PIN1 PKIG PLAC8 PLCB4 PLCD4 PMM2 PMS2 PNKP PNLIPRP1 POLR1A POLR1C POLR3GL POM121C POMT1 PPP1CB PPP1R18 PRAP1 PRKAB2 PRKAG1 PRKCI PRKG1 PRKN PRL PRMT3 PRPF18 PRPF31 PRR19 PSMB10 PSMB8 PSMC1 PSMD14 PSMD9 PSME3 PTGER3 PWWP3A PXT1 RAB11B RAB2B RAB41 RAB6B RAD51B RAD51D RAD52 RAP1GAP2 RARB RASAL2 RBM10 RBM5 RBPJL RCHY1 RECK RELA RFTN2 RFX3 RGS5 RHOJ RIMS3 RIPPLY1 RMND5A RND2 RNF25 RNF40 RNF41 RNF6 RPL15 RPL23 RPP40 RPS4Y1 RRP8 RUNX1T1 RWDD2B SAE1 SAMD4A SAMM50 SAT1 SATB1 SCAF1 SCARF1 SCG5 SCIMP SCNM1 SCRN2 SDCBP SEC14L4 SEC63 SELENOP SET SFTPB SH2D1B SH2D4A SHFL SHISA3 SIRPB1 SKP1 SLC22A23 SLC23A1 SLC24A5 SLC25A17 SLC25A31 SLC27A5 SLC48A1 SLC66A1L SLC9A8 SLIT1 SMAD3 SMARCE1 SMG6 SMYD1 SNRPF SPANXN2 SPANXN3 SPATA1 SPEG SPON1 SPP1 SPRED1 SPRY1 SPRY2 SPRY3 SPTY2D1 SRSF11 SSX3 STAC STC1 STK11IP STK16 STRA8 STX11 STX16 STX6 STXBP1 SUFU SUSD4 SYNE2 SYT17 TAF1B TASOR2 TBC1D21 TBCEL TBL2 TBRG4 TBX6 TCEA2 TCEANC TCL6 TDO2 TEX14 TEX47 TGFB1 THRA TICAM2 TJAP1 TMEM100 TMEM14B TMEM266 TMPRSS11E TNPO3 TP53BP1 TPTE TRAF5 TRAF6 TRAPPC2L TRARG1 TRIM17 TRIM41 TRIM42 TRIM45 TRIM50 TRIML2 TRIP10 TRMT112 TRMT2A TSGA10IP TSPAN7 TSPO TSR2 TSSK1B TSTD2 TTC39B TTC9C TTLL10 TULP2 TXLNA TXLNB TXN2 TXNL4B U2AF1 UBA2 UBE2D1 UBE2K UBE3A UBL4A UBL4B UBXN2B UBXN8 UNC45A UPP2 USE1 USP20 USP32 UTP14C UTP23 UTP25 VAC14 VASN VBP1 VCX2 VDR VEZF1 VIP VMP1 VPS26C VWA5A VWC2L VWCE WDR37 WDR5 WFDC13 WFDC5 WFDC6 WFDC9 XPA XRCC2 YJU2 ZBED4 ZBED8 ZBTB16 ZBTB2 ZCWPW1 ZFP42 ZKSCAN3 ZKSCAN4 ZMAT2 ZMYND8 ZNF124 ZNF202 ZNF23 ZNF248 ZNF250 ZNF276 ZNF329 ZNF330 ZNF404 ZNF410 ZNF417 ZNF483 ZNF490 ZNF512B ZNF556 ZNF564 ZNF572 ZNF574 ZNF587 ZNF648 ZNF688 ZNF69 ZNF695 ZNF772 ZNF92	27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1
Entrez ID		4223	240
HPRD ID		02760	01065
Ensembl ID		ENSG00000106511	ENSG00000012779
Uniprot IDs		P50222	P09917
PDB IDs			2ABV 3O8Y 3V92 3V98 3V99 6N2W 6NCF
Enriched GO Terms of Interacting Partners?
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