Description |
mitogen-activated protein kinase kinase kinase 1 |
ubiquitin conjugating enzyme E2 D1 |
Image |
|
|
GO Annotations |
Cellular Component |
|
|
Molecular Function |
|
|
Biological Process |
|
|
Pathways |
|
|
Drugs |
|
|
Diseases |
|
|
GWAS |
- Alanine aminotransferase levels ( 33547301 33339817)
- Alanine transaminase levels ( 29403010)
- Blond vs. brown/black hair color ( 30531825)
- Body shape index ( 34021172)
- Brain morphology (MOSTest) ( 32665545)
- Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030)
- Breast cancer (early onset) ( 24493630)
- Brown vs. black hair color ( 30531825)
- Coronary artery disease ( 29212778)
- Cortical surface area (MOSTest) ( 32665545)
- Fasting blood insulin ( 25631608)
- Fasting glucose in pregnancy (gestational week 14-16) ( 30324795)
- Fasting insulin ( 33402679)
- Fasting insulin (dietary factor interaction) ( 24204828)
- Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828)
- Initial pursuit acceleration ( 29064472)
- Lung function (FEV1) ( 30061609)
- Refractive error ( 32231278)
- Serum alkaline phosphatase levels ( 33547301)
- Sexual dimorphism in anthropometric traits ( 23754948)
- Subcortical volume (MOSTest) ( 32665545)
- Triglyceride levels ( 28334899 32902719)
- Triglycerides ( 24097068 20686565)
- Type 2 diabetes ( 23209189)
- Urate levels (BMI interaction) ( 25811787)
- Waist circumference ( 23966867)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in active individuals ( 28448500)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412 28448500)
- Waist-hip index ( 34021172)
- Waist-hip ratio ( 25673412)
- Waist-to-hip ratio adjusted for BMI ( 34021172 26426971)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
- Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
- White matter hyperintensity volume ( 33293549)
- White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
- White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
- Youthful appearance (self-reported) ( 32339537)
|
|
Interacting Genes |
97 interacting genes:
ACTN1
APEX2
APPL1
ARHGAP4
ASCC2
ATXN3
BAALC
BAP1
BRCA1
CARD14
CCDC69
CD74
CEP85
CHRM5
CHUK
COPS6
CRELD1
CRTC1
CUEDC1
DCUN1D1
DCUN1D2
DENND6B
DNAJB2
DNAJB6
DTX1
EPHA1
EPN1
FAF2
FAM184A
FKBP6
GGA2
GRIPAP1
GSK3B
HBS1L
HGS
HIP1
IKBKB
ILRUN
IMPACT
KRT36
MAP2K4
MAP2K7
MAPK1
MAPK9
MBP
MINDY3
NEK10
NFKBIA
NOTCH1
NPLOC4
NR4A1
ODF2
PAK1
PLEKHB2
PSMD4
RAB3IL1
RABEP2
RAD18
RAD23A
RAD51AP1
RAF1
RBCK1
RIPK1
RNF114
RNF126
RNF141
SPART
STAM
STAM2
TAB1
TNIP1
TOM1
TOM1L2
TP53
TRAF2
UBAC1
UBAP1
UBASH3B
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2G1
UBE2I
UBE2K
UBE2L6
UBE2V1
UBE2W
UBQLN1
UBXN7
UCHL5
UFD1
USP28
YWHAE
ZFAND3
ZFAND5
|
233 interacting genes:
AMFR
ANAPC11
ANK3
ANXA1
ANXA7
AREL1
ARIH1
ARIH2
ARRDC3
ASB2
ASB4
ASB9
BABAM2
BARD1
BFAR
BIRC2
BIRC3
BIRC6
BIRC7
BIRC8
BRCA1
BRCC3
BRMS1
C7orf25
CADPS2
CBL
CBLC
CDK7
CDKN1A
CHFR
CNOT4
COP1
CRBN
CREBBP
CRYAB
CTNNB1
CUL2
CUL3
DDX58
DTL
DTX1
DTX2
DTX3
DTX3L
DYRK2
DZIP3
EP300
EPS15
F12
FAF2
FBXL2
FBXO2
FBXO7
FOS
FZR1
GADD45A
GSK3B
HDAC6
HECW1
HERC2
HERC3
HERC5
HIF1A
HSD17B10
HUWE1
ITCH
KAT2B
KCTD17
KDM2B
KEAP1
KLHL13
KLHL2
KLHL9
LNPK
LRR1
LRSAM1
LTN1
MAP3K1
MARCHF1
MARCHF2
MARCHF4
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEOX2
MGRN1
MIB1
MID1
MID2
MKNK1
MKRN1
MKRN2
MKRN3
MUL1
NBN
NEDD4
NEDD4L
NEURL1
NFKBIA
NHLRC1
NQO1
NR1H2
OBI1
OTUB1
PELI1
PJA2
PMAIP1
POLL
POLM
PRKN
RABGEF1
RAG1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF128
RNF13
RNF130
RNF14
RNF144A
RNF150
RNF165
RNF166
RNF167
RNF168
RNF181
RNF182
RNF185
RNF2
RNF216
RNF25
RNF26
RNF31
RNF38
RNF4
RNF43
RNF5
RNF6
RNF7
RNF8
SH3RF1
SHPRH
SIAH1
SIAH2
SIRT6
SIVA1
SKP1
SMURF1
SPOP
STAM2
STUB1
TAF1D
TBL1X
TMEM129
TNFAIP3
TNNT1
TOM1
TOPORS
TRAF2
TRAF4
TRAF6
TRAF7
TRAIP
TRIM10
TRIM17
TRIM2
TRIM21
TRIM22
TRIM23
TRIM24
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM69
TRIM7
TRIM8
TRIP12
TSC22D1
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE3C
UBE4A
UBOX5
UBTD1
UFM1
UHRF1
UHRF2
USP21
UVSSA
VHL
WWP1
WWP2
XIAP
ZNF598
ZNRF1
ZNRF2
ZNRF4
|
Entrez ID |
4214 |
7321 |
HPRD ID |
19599 |
04267 |
Ensembl ID |
ENSG00000095015
|
ENSG00000072401
|
Uniprot IDs |
Q13233
|
A0A024QZJ2
A0A087WW00
P51668
|
PDB IDs |
6WHB
|
2C4P
2YHO
3OJ4
3PTF
4AP4
4QPL
5FER
5TUT
6D4P
|
Enriched GO Terms of Interacting Partners? |
|
|
Tagcloud ? |
|
|
Tagcloud (Difference) ? |
|
|
Tagcloud (Intersection) ? |
|